Assistant Professor Medical College of Wisconsin, Versiti Blood Research Institute Milwaukee
Please view the 2023 RPTH State-of-the-Art Illustrated Capsules here.
Learning Objectives:
The hepatocyte-derived tPA contributes to basal blood tPA concentration, and works in concert with tPA released from endothelium upon vascular injury, thereby initiating fibrinolysis.
A balance between tPA and PAI1 in plasma is important for breaking down fibrin clot without compromising clotting.
In hepatocytes, where lipids are loaded and incorporated into lipoproteins, the imbalanced PAI-1-tPA production influences the degree of impaired fibrinolysis in obesity.
