OC 70 - Contact Pathway: Structure and Function II

Moderator(s)

• 

  Helen Philippou, PhD

  Professor
  LICAMM
  University of Leeds.
  Leeds, England, United Kingdom
• SR

  Stephanie Reitsma

Presentations:

• 10:15 – 10:30 ET

  High molecular kininogen cleavage in cerebral malaria
  

  Presenting Author: Alessandro Pinheiro, PhD (he/him/his) – Division of Hematology and Oncology Department of Medicine Case Western Reserve University

  Co-Author: Sadiq Silbak, BS, MS – Department of Pathology, Case Western Reserve University

  Co-Author: Alona Merkulova – Division of Hematology and Oncology Department of Medicine Case Western Reserve University

  Co-Author: Yelenna Skomorovska-Prokvolit – Centre for Global Health and Diseases, Case Western Reserve University

  Co-Author: Keith R. McCrae – Cleveland Clinic Foundation, Cleveland, OH, USA

  Co-Author: David Midem – Chulaimbo Sub-county Hospital

  Co-Author: Sidney Ogolla – Kenya Medical Research Institute

  Co-Author: Arlene Dent – Department of Pediatrics, Centre for Global Health and Diseases, Case Western Reserve University

  Co-Author: Ana Acacia Pinheiro – Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro

  Co-Author: James Kazura – Centre for Global Health and Diseases, Case Western Reserve University

  Co-Author: Alvin Schmaier – Division of Hematology and Oncology Department of Medicine Case Western Reserve University
• 10:30 – 10:45 ET

  The first insight into the spatial structure of human kininogen by cryogenic electron microscopy and computational methods
  

  Presenting Author: Michal B. Ponczek, PhD DSc (he/him/his) – University of Lodz, Faculty of Biology and Environmental Protection, Department of General Biochemistry

  Co-Author: Patrycja Dębska – University of Lodz, Faculty of Biology and Environmental Protection, Department of General Biochemistry
• 10:45 – 11:00 ET

  Effect of High-Molecular-Weight Kininogen Binding to Factor XI and Prekallikrein on Thrombosis
  

  Presenting Author: Bassem M. Mohammed, BPharm, PhD (he/him/his) – Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

  Co-Author: Mao-fu Sun – Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center

  Co-Author: Qiufang Chen – Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center

  Co-Author: Priyanka Srivastava, PhD – Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center

  Co-Author: Sunil Kumar – Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center

  Co-Author: Owen J.T McCarty, PhD, FAHA – Oregon Health & Science University

  Co-Author: David Gailani, MD – Vanderbilt University Medical Center
• 11:00 – 11:15 ET

  Thrombin activation of the factor XI dimer is a multi-staged process for each subunit
  

  Presenting Author: Awital Bar Barroeta, PhD (she/her/hers) – Sanquin, Dept. Molecular Hematology, Amsterdam, The Netherlands

  Co-Author: Pascal Albanese – Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

  Co-Author: J. Arnoud Marquart – Department of Molecular Hematology, Sanquin, Amsterdam, the Netherlands

  Co-Author: Richard A. Scheltema – Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

  Co-Author: Joost CM Meijers – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands
• 11:15 – 11:30 ET

  Coagulation factor XI contributes to the infarct size and inflammation in myocardial ischemia/reperfusion injury
  

  Presenting Author: Qi Luo – University Medical Center Mainz, Germany

  Co-Author: Michael Molitor – University Medical Center Mainz, Germany

  Co-Author: Melania Aluia – University Medical Center Mainz, Germany

  Co-Author: Stefanie Finger – University Medical Center Mainz, Germany

  Co-Author: Philip Wenzel, MD (he/him/his) – Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz