OC 22 - Pathogenesis of COVID-19 Coagulopathy

Moderator(s)

• MB

  Mark Blostein, MDCM

  Physician
  Jewish General Hospital
  Mount Royal, Quebec, Canada
• 

  Patricia Liaw, PhD (she/her/hers)

  Professor, Principal Investigator
  McMaster University - The Thrombosis & Atherosclerosis Research Institute
  Hamilton, Ontario, Canada

Presentations:

• 14:45 – 15:00 ET

  Proteome and phosphoproteome analyses of SARS-CoV-2 infected humanized ACE2 mice platelets revealed reprogramming of platelets from early hyperreactive to late antiviral phenotypes
  

  Presenting Author: Saravanan Subramaniam, PhD (he/him/his) – Boston University

  Co-Author: Ryan Matthew Hekman – Center for Network Systems Biology, Boston University, Boston, MA, USA

  Co-Author: Archana Jayaraman – Pulmonary Center, Department of Medicine, School of Medicine, Boston University MA, USA

  Co-Author: Devin Kenney – National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA

  Co-Author: Aoife Kateri O'Connell – National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA

  Co-Author: Paige Montanaro – National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA

  Co-Author: Benjamin Blum – Center for Network Systems Biology, Boston University, Boston, MA, USA

  Co-Author: Sarah Walachowski – Pulmonary Center, Department of Medicine, School of Medicine, Boston University MA, USA

  Co-Author: Maria Ericsson – Electron Microscopy Core Facility, Harvard Medical School, Boston, MA, USA

  Co-Author: Katya Ravid – Department of Medicine and Whitaker Cardiovascular Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA

  Co-Author: Nicholas A Crossland – National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA

  Co-Author: Andrew Emili – Center for Network Systems Biology, Boston University, Boston, MA, USA

  Co-Author: Florian Douam – National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, USA

  Co-Author: Markus Bosmann – Pulmonary Center, Department of Medicine, School of Medicine, Boston University MA, USA
• 15:00 – 15:15 ET

  Endothelial activation and von Willebrand Factor role in COVID-19-associated coagulopathy.
  

  Presenting Author: Roberto Aiolfi, PhD – The Scripps Research Institute

  Co-Author: Hiroshi Deguchi – The Scripps Research Institute

  Co-Author: José A Fernández – Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA

  Co-Author: Jeanine Ahmed – The Scripps Research Institute

  Co-Author: Miriam Hauer-Jensen – The Scripps Research Institute

  Co-Author: Sachiko Kanaji – The Scripps Research Institute

  Co-Author: Zaverio Ruggeri – The Scripps Research Institute

  Co-Author: Juan Carlos de la Torre – The Scripps Research Institute

  Co-Author: Laurent O. Mosnier, PhD – Scripps Research
• 15:15 – 15:30 ET

  Monocytes and Macrophages Promote Increased Tissue Factor/Factor VIIa-Dependent Procoagulant Activity in Response to the SARS-CoV-2 Spike Protein
  

  Presenting Author: James V. Harte (he/him/his) – Signal Transduction Laboratory, School of Biochemistry & Cell Biology, University College Cork, Western Gateway Building, T12 XF62 Cork, Ireland

  Co-Author: Caroline Coleman-Vaughan – Department of Biological Sciences, Munster Technological University, T12 P928 Cork, Ireland

  Co-Author: Justin V. McCarthy – Signal Transduction Laboratory, School of Biochemistry & Cell Biology, University College Cork, Western Gateway Building, T12 XF62 Cork, Ireland

  Co-Author: Maeve P. Crowley – Department of Haematology, Cork University Hospital, Wilton, T12 DC4A Cork, Ireland

  Co-Author: Vitaliy Mykytiv – Department of Haematology, Cork University Hospital, Wilton, Cork, T12 DC4A Ireland
• 15:30 – 15:45 ET

  SARS-CoV-2 protein ORF3a promotes release of procoagulant tissue factor-positive extracellular vesicles
  

  Presenting Author: Shabbir A. Ansari, PhD – Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Jacob Ludington – Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Keiichi Enjyoji – Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Papa Anderson – Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Getulio Pereira de Oliveira Junior – Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, MA

  Co-Author: Ionita Ghiran – Department of Anaesthesia, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Robert E. Schwartz – Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY

  Co-Author: Alec Schmaier – Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Sol Schulman, MD, PhD (he/him/his) – Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
• 15:45 – 16:00 ET

  Effect of angiostatin and its neutralization on cellular infection by SARS-CoV and SARS-CoV-2
  

  Presenting Author: Aleksandra Franczak, MSc (she/her/hers) – Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta

  Co-Author: Michael Joyce – Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

  Co-Author: Max s. Saito – Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

  Co-Author: Lorne Tyrrell – Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

  Co-Author: Paul Jurasz – Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada