OC 23 - Engineering Platelets to Work for Us in Diagnosis and Treatment

Moderator(s)

• 

  Christian Kastrup, PhD

  Senior Investigator
  Versiti Blood Research Institute
  Wauwatosa, Wisconsin, United States
• 

  Imane Boukhatem, MSc

  PhD candidate
  Research Center
  Faculty of pharmacy, University of Montreal
  Montreal, Quebec, Canada

Presentations:

• 14:45 – 15:00 ET

  Transfusion of RNA-Edited Platelets in a Rodent Model of Polytrauma: A Pilot Study
  

  Presenting Author: Jerry Leung (he/him/his) – The University of British Columbia

  Co-Author: Katherine Badior, PhD – Versiti Blood Research Institute

  Co-Author: Colton Strong (he/him/his) – The University of British Columbia

  Co-Author: Xiaowu Wu – U.S. Army Institute of Surgical Research

  Co-Author: Michael Meledeo – U.S. Army Institute of Surgical Research

  Co-Author: Eric Jan – University of British Columbia

  Co-Author: Dana Devine – The University of British Columbia

  Co-Author: Pieter Cullis – The University of British Columbia

  Co-Author: Christian Kastrup, PhD – Versiti Blood Research Institute
• 15:00 – 15:15 ET

  In vitro generated megakaryocytes for the detection of HPA alloantibodies in clinical samples
  

  Presenting Author: Günalp Uzun, MD (he/him/his) – Center for Clinical Transfusion Medicine, University Hospital of Tübingen

  Co-Author: Josip Lucic – Department of Transfusion Medicine, Cellular Therapeutics and Hemostaseology, Clinic for Anesthesiology LMU University Hospital Munich, Germany.

  Co-Author: Flavianna Rigoni – Center for Clinical Transfusion Medicine

  Co-Author: Franziska Lyshy – Center for Clinical Transfusion Medicine

  Co-Author: Irene Marini – Center for Clinical Transfusion Medicine

  Co-Author: Stefanie Nowak-Harnau – Center for Clinical Transfusion Medicine

  Co-Author: Karina Althaus, MD – Center for Clinical Transfusion Medicine, University Hospital of Tübingen

  Co-Author: Ulrich Sachs, PhD – Institute for Clinical Immunology, Transfusion Medicine and Hemostasis, Justus-Liebig-University, Langhansstr. 7, 35392 Giessen, Germany.

  Co-Author: Tamam Bakchoul, MD (he/him/his) – Center for Clinical Transfusion Medicine, University Hospital of Tübingen
• 15:15 – 15:30 ET

  Naked miRNA mimics and siRNAs selectively transfect megakaryocytes and platelets in vivo and durably suppress target gene expression to modulate megakaryocyte and platelet function in mice.
  

  Presenting Author: Lawrence E. Goldfinger, PhD (he/him/his) – Thomas Jefferson University

  Co-Author: Jeremy Wurtzel – Thomas Jefferson University
• 15:30 – 15:45 ET

  Functional characterization of a nanobody based GPVI specific platelet agonist
  

  Presenting Author: Minka Zivkovic, MSc – Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

  Co-Author: Elisabeth Pols - van Veen – Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

  Co-Author: Silvie AE Sebastian – Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, the Netherlands

  Co-Author: Suzanne JA Korporaal – Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, the Netherlands

  Co-Author: Rolf T. Urbanus, PhD – Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
• 15:45 – 16:00 ET

  National External Quality Assessment Scheme (NEQAS BC) and Welsh Blood Service (WBS) use cold-stored platelets for External Quality Assessment (EQA) scheme for Light Transmission Aggregometry (LTA).
  

  Presenting Author: Christopher Mark Peter Reilly-Stitt, MSc – UK NEQAS BC

  Co-Author: Ian Jennings – UK NEQAS BC

  Co-Author: Steve Kitchen, PhD – Sheffield Haemophilia and Thrombosis Centre

  Co-Author: Isobel Walker – UK NEQAS BC

  Co-Author: Christine Saunders – Welsh Blood Service

  Co-Author: Chloe George – Welsh Blood Service

  Co-Author: Thomas Scorer – University Hospital Plymouth,