OC 57 - High Throughput Methods for Improved Understanding of Coagulation and Bleeding

Moderator(s)

• 

  Jill Johnsen, MD (she/her/hers)

  Associate Professor, Division of Hematology
  University of Washington, Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA
  Seattle, Washington, United States
• 

  Laura Raffield, PhD (she/her/hers)

  Assistant Professor, Department of Genetics
  University of North Carolina Chapel Hill
  Chapel Hill, North Carolina, United States

Presentations:

• 10:45 – 11:00 ET

  Peptidomics reveals expected and unexpected proteolytic events in plasma upon activation of the coagulation cascade
  

  Presenting Author: Jessica Del Castillo Alferez, Msc (she/her/hers) – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.

  Co-Author: Floris Van Alphen – Department of Molecular Hematology, Sanquin Research, 1066 CX Amsterdam, the Netherlands

  Co-Author: Carmen van der Zwaan – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.

  Co-Author: Marleen Zuurveld – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Kamran Bakhtiari – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.

  Co-Author: Arie J. Hoogendijk, PhD – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.

  Co-Author: Herm-Jan M. Brinkman, PhD (he/him/his) – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Joost CM Meijers – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Alexander B. Meijer – Department of Molecular Hematology, Sanquin Research, 1066 CX Amsterdam, the Netherlands
• 11:00 – 11:15 ET

  Integrated proteomic and computational approach reveals determinants of bleeding risk in factor XI deficiency
  

  Presenting Author: Stéphanie E. Reitsma, PhD – Department of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

  Co-Author: Suzanne Sindi – Department of Applied Mathematics, University of California Merced

  Co-Author: Daniel Kissau – Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus

  Co-Author: John Burthem – Department of Haematology, Manchester Royal Infirmary, Institute of Cancer Sciences, The University of Manchester

  Co-Author: Paula H.B Bolton-Maggs, DM – Division of Cardiovascular Sciences, The University of Manchester, Manchester

  Co-Author: Gillian Gidley – Leeds Teaching Hospitals Trust

  Co-Author: Kirk Hansen – Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus

  Co-Author: Karin Leiderman, PhD (she/her/hers) – University of North Carolina at Chapel Hill

  Co-Author: Alisa S. Wolberg, PhD – Univerisity of North Carolina at Chapel Hill
• 11:15 – 11:30 ET

  Genome-wide identification of loci controlling plasma coagulation factor IX activity
  

  Presenting Author: Jihee Han, MS – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Ruifang Li-Gao, PhD (she/her/hers) – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Renée de Mutsert – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Frits R. R. Rosendaal – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Alejandro Pallares Robles – Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz (UMCM), Mainz, Germany

  Co-Author: Vincent ten Cate – Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz (UMCM), Mainz, Germany

  Co-Author: Philipp S. S. Wild – Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz (UMCM), Mainz, Germany

  Co-Author: Astrid van Hylckama Vlieg, PhD – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
• 11:30 – 11:45 ET

  Deciphering novel complex structural variations in severe hemophilia A patients by optical genome mapping
  

  Presenting Author: somayyeh fahiminiya, PhD (she/her/hers) – Division of Hematology-Oncology, Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

  Co-Author: Spyros Oikonomopoulos – McGill Genome Centre, Department of Human Genetics, McGill University, Montreal, Québec, Canada.

  Co-Author: Georges-Etienne Rivard – Division of Hematology-Oncology, Department of Pediatrics, Université de Montréal, CHU Sainte-Justine, Montréal, Quebec, Canada

  Co-Author: Mira Gandhi – Pacific Northwest Research Institute (PNRI), Seattle, Washington, USA.

  Co-Author: Patrick Scott – Molecular Diagnostic Laboratory, CHU Sainte-Justine, Montréal, Québec, Canada.

  Co-Author: Alexandre Montpetit – Centre d'expertise et de services Génome Québec, Montréal, Québec, Canada.

  Co-Author: Shu-Huang Chen – McGill Genome Centre, Department of Human Genetics, McGill University, Montreal, Québec, Canada.

  Co-Author: KyungHee park – Pacific Northwest Research Institute (PNRI), Seattle, Washington, USA

  Co-Author: Catherine Vezina – Montréal Children's Hospital, McGill University Health Center, Montréal, Québec, Canada.

  Co-Author: Jean St-Louis – Division of Hematology-Oncology, Department of Pediatrics, Université de Montréal, CHU Sainte-Justine, Montréal, Quebec, Canada.

  Co-Author: Jiannis Ragoussis – McGill Genome Centre, Department of Human Genetics, McGill University, Montreal, Québec, Canada.

  Co-Author: Claudia M. B. Carvalho – Pacific Northwest Research Institute (PNRI), Seattle, Washington, USA.

  Co-Author: Grant A. Mitchell – Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montreal, Québec, Canada

  Co-Author: Jean-Francois Soucy – Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montreal, Québec, Canada.

  Co-Author: Julie Gauthier – Molecular Diagnostic Laboratory, CHU Sainte-Justine, Montréal, Québec, Canada.
• 11:45 – 12:00 ET

  Platelet Aggregation and Transcriptomic Profiling Informs Perioperative Bleeding Risk
  

  Presenting Author: Tessa J. Barrett, PhD – NYU Grossman School of Medicine

  Co-Author: Gustavo Hernandez – NYU Grossman School of Medicine

  Co-Author: MacIntosh Cornwell – NYU Grossman School of Medicine

  Co-Author: Yuhe Xia – NYU Grossman School of Medicine

  Co-Author: Nathaniel Smilowitz – NYU Grossman School of Medicine

  Co-Author: Kelly Ruggles – NYU Grossman School of Medicine

  Co-Author: Judith Hochman – NYU Grossman School of Medicine

  Co-Author: Jeffrey S. Berger – New York University Grossman School of Medicine