OC 33 - Hemophilia Basic Science - Novel Therapies and Joint Disease

Moderator(s)

• 

  Jean St-Louis, MD, FRCPC (he/him/his)

  Associate Professor
  Université de Montréal
  Montreal, Quebec, Canada
• 

  Jordan Shavit, MD, PhD (he/him/his)

  Professor
  Department of Pediatrics and Department of Human Genetics, University of Michigan Medical School
  Ann Arbor, Michigan, United States

Presentations:

• 10:45 – 11:00 ET

  Neutrophil extracellular traps promote gasdermin-D-dependent joint damage in hemophilia
  

  Presenting Author: Tomasz W. Kaminski, PharmD – University of Pittsburgh

  Co-Author: Tomasz Brzoska, PhD (he/him/his) – University of Pittsburgh

  Co-Author: Omika Katoch – University of Pittsburgh

  Co-Author: Margaret V. Ragni, MD, MPH (she/her/hers) – Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

  Co-Author: Prithu Sundd, PhD (he/him/his) – University of Pittsburgh
• 11:00 – 11:15 ET

  Maladaptive Lymphangiogenesis is Associated with Synovial Iron Accumulation and Delayed Clearance in FVIII-/- Mice After Induced Hemarthrosis
  

  Co-Author: Bilgimol Chumappumkal Joseph, PhD – University of California San Diego

  Co-Author: Esther Cooke – University of California San Diego

  Co-Author: Chanond Nasamran – University of California San Diego

  Co-Author: Kathleen Fisch – University of California San Diego

  Presenting Author: Annette von Drygalski, MD – University of California San Diego
• 11:15 – 11:30 ET

  Evaluating the impact of anti-PEG antibodies on activation of PEGylated therapeutic FVIII products
  

  Presenting Author: Behnaz Pezeshkpoor, PhD (she/her/hers) – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Ann-Cristin Berkemeier – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Isabell Matuschek – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Katrin Hartlieb – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Johannes Oldenburg, MD (he/him/his) – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany
• 11:30 – 11:45 ET

  Loss of Factor VIII in Zebrafish Does Not Result in Severe Hemophilia A Due to an Altered Balance with Natural Anticoagulants
  

  Presenting Author: Catherine E. RIchter, MS (she/her/hers) – University of Michigan

  Co-Author: Jordan A. Shavit, MD, PhD (he/him/his) – Department of Pediatrics and Department of Human Genetics, University of Michigan Medical School
• 11:45 – 12:00 ET

  Structural characterization of coagulation factor VIII
  

  Presenting Author: Samhitha Urs Ramaraje Urs, MSc – Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn

  Co-Author: Sneha Singh, PhD (she/her/hers) – Institute of Experimental Hematology and Transfusion Medicine, University Clinic Bonn

  Co-Author: Haroon Javed, MSc – Institute of Experimental Haematology and Transfusion Medicine, University Hospital Bonn

  Co-Author: MD Mubassherul Islam – Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn

  Co-Author: Deniz Ugurlar – Materials and Structural Analysis Division, Thermo Fisher Scientific, Achtseweg Noord, 5651 GG Eindhoven, the Netherlands.

  Co-Author: Boxue Ma – Materials and Structural Analysis Division, Thermo Fisher Scientific, Achtseweg Noord, 5651 GG Eindhoven, the Netherlands

  Co-Author: Jean Luc Pellequer – Institut de Biologie Structurale, Methods and Electron Microscopy group, Grenoble, France

  Co-Author: Jean-Marie Teulon – Institut de Biologie Structurale, Methods and Electron Microscopy group, Grenoble, France

  Co-Author: Daphna Fenel – Institut de Biologie Structurale, Methods and Electron Microscopy group, Grenoble, France

  Co-Author: Anna Pepanian – University of Bonn

  Co-Author: Diana Imhof – University of Bonn

  Co-Author: Johannes Oldenburg, MD (he/him/his) – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Arijit Biswas, PD Dr (Biol) – Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn