OC 24 - Hemophilia Clinical – Factor Levels and Pharmacokinetics

Moderator(s)

• 

  Courtney Thornburg, MD, MS (she/her/hers)

  Professor of Pediatrics
  Rady Children's Hospital-San Diego
  San Diego, California, United States
• 

  Guy Young, MD

  Director, Hemostasis and Thrombosis Center
  Pediatrics
  Children's Hospital Los Angeles
  Los Angeles, California, United States

Presentations:

• 14:45 – 15:00 ET

  Effect of the type of F9 mutation on the pharmacokinetic profile of patients with hemophilia B treated with extended half-life FIX concentrates.
  

  Presenting Author: Davide Matino, MD (he/him/his) – Department of Medicine, Division of Hematology, McMaster University, Hamilton, ON

  Co-Author: Pierre Chelle, PhD – University of Waterloo

  Co-Author: Shannon Jackson, MD (she/her/hers) – Providence Hematology, St. Paul’s Hospital, Vancouver, BC, Canada

  Co-Author: Jerome Teitel, MD – St Michael's Hospital Haemophilia Treatment Centre, University of Toronto

  Co-Author: Giancarlo Castaman, MD – Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy

  Co-Author: Arun Keepanasseril – Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Canada

  Co-Author: Emma Iserman – Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON

  Co-Author: David Lillicrap, MD – Department of Pathology and Molecular Medicine, Queen's University

  Co-Author: Anthony KC. Chan, MBBS – McMaster University, McMaster Children’s Hospital, Hamilton, Canada

  Co-Author: Alfonso Iorio – Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON
• 15:00 – 15:15 ET

  Estimated Factor VIII Activity Levels at the Time of Bleeding Events in Individuals with Hemophilia A without Inhibitors
  

  Presenting Author: Pierre Chelle, PhD – University of Waterloo

  Co-Author: Dagmar Hajducek – University of Waterloo

  Co-Author: Nabil Daoud – American Thrombosis and Hemostasis Network

  Co-Author: Emma Iserman – Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON

  Co-Author: Christine Gerber – American Thrombosis and Hemostasis Network

  Co-Author: Federico Germini, MD, MSc, PhD – Department of Medicine, McMaster University, Hamilton, ON

  Co-Author: Alfonso Iorio – Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON

  Co-Author: Andrea Edginton – University of Waterloo

  Co-Author: Michael Recht, MD, PhD, MBA (he/him/his) – National Hemophilia Foundation
• 15:15 – 15:30 ET

  Minimum Baseline FVIII Levels Required to Prevent Joint Bleeding Episodes: a Study in Mild Hemophilia A
  

  Presenting Author: Pasquale Agosti, MD, PhD – Università degli Studi di Milano, Department of Pathophysiology and Transplantation and Fondazione Luigi Villa, Milan, Italy

  Co-Author: Simona Maria Siboni – Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center

  Co-Author: Sara Scardo – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy

  Co-Author: Roberta Gualtierotti, MD, PhD – Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Centro Emofilia e Trombosi Angelo Bianchi Bonomi

  Co-Author: Flora Peyvandi, MD, PhD (she/her/hers) – IRCCS Ca' Granda Maggiore Hospital Foundation, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy
• 15:30 – 15:45 ET

  Effect of F8 mutations and Von Willebrand factor on pharmacokinetics of FVIII concentrates in severe hemophilia A
  

  Presenting Author: Federico Germini, MD, MSc, PhD – Department of Medicine, McMaster University, Hamilton, ON

  Co-Author: Zainab S. Al Housni, Bhcs, MD, FRCPath – McMaster University

  Co-Author: Anthony KC. Chan, MBBS – McMaster University, McMaster Children’s Hospital, Hamilton, Canada

  Co-Author: Kay Decker – Hamilton Health Scienes

  Co-Author: Alfonso Iorio – Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON

  Co-Author: Davide Matino, MD (he/him/his) – Department of Medicine, Division of Hematology, McMaster University, Hamilton, ON
• 15:45 – 16:00 ET

  A Phase 1 Study to Evaluate the Pharmacokinetics and Safety of a PEGylated-Recombinant Human Coagulation Factor VIII-Fc Fusion Protein in Patients With Severe Hemophilia A
  

  Co-Author: Feng Xue, MD – Institute of haematology and Blood Diseaes Hospital, Chinese Academy of Medical Sciences and Pkeing Union Medical College

  Co-Author: Yun Chen – Jinan central hospital, Shandong, P.R. China

  Co-Author: Jing Sun – Nanfang Hospital of Southern Medical University, Guangzhou, P.R. China

  Co-Author: Shuxia Guo – Zhengzhou People's Hospital

  Co-Author: Qing Wen – Jinan central hospital, Shandong, P.R. China

  Co-Author: Chongyuan Xu – Nanfang Hospital of Southern Medical University, Guangzhou, P.R. China

  Co-Author: Ping Liu – Zhengzhou People's Hospital

  Presenting Author: Renchi Yang, MD (he/him/his) – Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China