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    Oral Communication

    Immunothrombosis
    Oral Communication Session

    OC 55 - Pathological Immunothrombosis

    Tuesday, June 27, 2023
    10:45 – 12:00 ET
    Room:510

    Session Available Online As: On-Demand

    Presentations:

    • 10:45 – 11:00 ET
      Balance between neutrophil extracellular trap formation and DNase activity in COVID-19 patients

      Presenting Author: Geoffrey Garcia, PharmD (he/him/his) – University of Bordeaux, INSERM UMR 1034, Biology of cardiovascular diseases, Pessac, France

      Co-Author: Sylvie Labrouche-Colomer – University of Bordeaux, INSERM UMR 1034, Biology of cardiovascular diseases, Pessac, France

      Co-Author: Alexandre Duvignaud – INSERM UMR 1219, Bordeaux Population Health Research Centre, Bordeaux, France

      Co-Author: Etienne Clequin – CNRS, UMR5164 ImmunoConcEpT, Bordeaux University, Bordeaux, France

      Co-Author: Charles Dussiau – University of Bordeaux, INSERM UMR 1034, Biology of cardiovascular diseases, Pessac, France

      Co-Author: David-Alexandre TREGOUET, PhD (he/him/his) – Bordeaux Population Health research center - INSERM UMR1219

      Co-Author: Denis Malvy – INSERM UMR 1219, Bordeaux Population Health Research Centre, Bordeaux, France.

      Co-Author: Renaud Prével – Univ Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, Inserm UMR 1045, F-33000 Bordeaux, France

      Co-Author: Julien Goret – CNRS, UMR5164 ImmunoConcEpT, Bordeaux University, Bordeaux, France

      Co-Author: Maria Mamani-Matsuda – CNRS, UMR5164 ImmunoConcEpT, Bordeaux University, Bordeaux, France

      Co-Author: Antoine Dewitte – CNRS, UMR5164 ImmunoConcEpT, Bordeaux University, Bordeaux, France

      Co-Author: Chloé James – University of Bordeaux, INSERM UMR 1034, Biology of cardiovascular diseases, Pessac, France

    • 11:00 – 11:15 ET
      Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

      Presenting Author: Tristram A.J Ryan, BSc PhD (he/him/his) – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Alexander Hooftman – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Aisling M. M. Rehill – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons, Dublin 2, Ireland

      Co-Author: Matt D. Johansen – Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia

      Co-Author: Eóin C. O'Brien – Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Juliana E. Toller-Kawahisa – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Emily A. Day – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Hauke J. Weiss – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Christian G. Peace – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Alessia Zotta – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Nicole G. Hansbro – Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia

      Co-Author: James S. O'Donnell, MB, PhD – Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland,Dublin, Ireland

      Co-Author: Philip M. Hansbro – Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia

      Co-Author: Rachel M. McLoughlin – Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Małgorzata Wygrecka – Center for Infection and Genomics of the Lung, Faculty of Medicine, Justus Liebig University, Giessen, Germany

      Co-Author: Roger J.S. Preston, PhD – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons, Dublin 2, Ireland

      Co-Author: Zbigniew Zasłona – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

      Co-Author: Luke A.J. O'Neill, FRS – School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

    • 11:15 – 11:30 ET
      Inflammasome activation in vaccine-induced thrombotic thrombocytopenia (VITT) after immunization with adenovirus-based SARS-CoV-2 vaccines

      Presenting Author: Remy Martins-Gonçalves, MD (he/him/his) – Fiocruz, Rio de Janeiro, Brazil

      Co-Author: Daniela P. Mendes-De-Almeida – Department of Medical Affairs, Clinical Studies, and Post-Registration Surveillance (DEAME), Institute of Technology in Immunobiologicals/Bio-Manguinhos, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil

      Co-Author: Carolina Q. Sacramento – National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil.

      Co-Author: Stephane Vicente Rozini – - Laboratory of Immunothrombosis, Department of Biochemistry, Federal University of Juiz de Fora, Juiz de Fora, Brazil

      Co-Author: Joanna Bokel – Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil

      Co-Author: Gabriellen Vitiello Teixeira – - Institute of Technology in Immunobiologicals/Bio-Manguinhos/Fiocruz, Rio de Janeiro, Brazil

      Co-Author: Victor Bertollo Gomes Porto – - General Coordination of the National Immunization Program/National Immunization Program/ Brazilian Ministry of Health, Brazil

      Co-Author: Sandra Wagner Cardoso – - Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

      Co-Author: Brenda Hoagland – - Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

      Co-Author: Patricia Mouta Nunes De Oliveira – - Institute of Technology in Immunobiologicals/Bio-Manguinhos/Fiocruz, Rio de Janeiro, Brazil

      Co-Author: Luiz Amorim Filho – - Hemorio, Rio de Janeiro, Brazil.

      Co-Author: Beatriz Grinsztejn – - Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil

      Co-Author: Eugênio D. Hottz – Laboratory of Immunothrombosis, Department of Biochemistry, Federal University of Juiz de Fora, Juiz de Fora, Brazil

      Co-Author: Maria de Lourdes De Sousa Maia – - Institute of Technology in Immunobiologicals/Bio-Manguinhos/Fiocruz, Rio de Janeiro, Brazil

      Co-Author: Patricia T. Bozza – - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.

    • 11:30 – 11:45 ET
      Recombinant human anti-PF4 IgGs regenerated from VITT sera activate platelets and endothelial cells

      Presenting Author: Jing Jing Wang, PhD (she/her/hers) – Department of Immunology, College of Medicine and Public Health, Finders University

      Co-Author: Marijn van der Neut Kolfschoten – Janssen Vaccines & Prevention B.V.

      Co-Author: Lucy Rutten – Janssen Vaccines & Prevention B.V.

      Co-Author: Brittany Hill – Institute for Molecular Bioscience, Division of Cell and Developmental Biology, The University of Queensland

      Co-Author: Chee Wee TAN – SA Pathology, Adelaide, SA, Australia

      Co-Author: Rinke Bos – Janssen Vaccines & Prevention B.V.

      Co-Author: Annemart Koornneef – Janssen Vaccines & Prevention B.V.

      Co-Author: Rick Kapur – Sanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam

      Co-Author: Leendert Porcelijn – Department of Immunohematology Diagnostics, Sanquin Diagnostic Services

      Co-Author: Emma Gordon – Institute for Molecular Bioscience, Division of Cell and Developmental Biology, The University of Queensland

      Co-Author: Ted Kwaks – Janssen Vaccines & Prevention B.V.

      Co-Author: Laura Solforosi – Janssen Vaccines & Prevention B.V.

      Co-Author: Roland Zahn – Janssen Vaccines & Prevention B.V.

      Co-Author: Tom P. Gordon – Department of Immunology, College of Medicine and Public Health, Finders University

    • 11:45 – 12:00 ET
      Safe Nucleic acid Inhibitors That Show Protection Against Immunothrombosis in Sepsis

      Co-Author: Sreeparna Vappala, PhD (she/her/hers) – University of British Columbia

      Co-Author: Alina Reicherz – The Stone Centre at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

      Co-Author: Chanel La – Centre for Blood Research, University of British Columbia

      Co-Author: Haifeng Ji – University of British Columbia

      Co-Author: Srinivas Abbina – Centre for Blood Research, University of British Columbia

      Co-Author: Manu Thomas Kalathottukaren – Centre for Blood Research, University of British Columbia

      Co-Author: Matthew Drayton – Centre for Blood Research, University of British Columbia

      Co-Author: Roman Herout – The Stone Centre at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia

      Co-Author: Irina Chafeeva – Centre for Blood Research, University of British Columbia

      Co-Author: Cedric Carter – Centre for Blood Research, University of British Columbia

      Co-Author: James H. Morrissey, PhD – Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

      Co-Author: Edward M Conway, MD, PhD – Centre for Blood Research, University of British Columbia

      Co-Author: Charles A Haynes – Michael Smith Laboratories, Chemical & Biological Engineering, University of British Columbia

      Co-Author: Dirk Lange – The Stone Centre at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia

      Presenting Author: Jayachandran N. Kizhakkedathu, PhD (he/him/his) – Centre for Blood Research, University of British Columbia