OC 14 - Thrombotic Thrombocytopenic Purpura (TTP) Treatment

Moderator(s)

• 

  Kazuya SAKAI, MD, PhD

  Dr.
  Laboratory for Thrombosis Research
  Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk
  8500, West-Vlaanderen, Belgium
• 

  Christopher Patriquin, MD, MSc, FRCPC (he/him/his)

  Staff Physician
  Division of Hematology, University Health Network
  Toronto, Ontario, Canada

Presentations:

• 10:45 – 11:00 ET

  Phase 3 prospective, randomized, controlled, open-label, multicenter, crossover study of recombinant ADAMTS13 in patients with congenital thrombotic thrombocytopenic purpura
  

  Presenting Author: Marie Scully, MD – Department of Haematology, University College London Hospitals, London, UK

  Co-Author: Jerzy Windyga, Prof. dr med. (he/him/his) – Institute of Hematology and Transfusion Medicine

  Co-Author: Björn Mellgård – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Thomas L Ortel – Duke University, Durham, NC, USA

  Co-Author: Hong Li – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Mila Ayash-Rashkovsky – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Spero Cataland, MD (he/him/his) – Department of Internal Medicine, Ohio State University, Columbus, OH, USA

  Co-Author: Linda T Wang – Takeda Development Center Americas, Inc., Cambridge, MA, USA
• 11:00 – 11:15 ET

  Pharmacokinetic characteristics of ADAMTS13 in patients with congenital thrombotic thrombocytopenic purpura: Interim results from a phase 3 randomized, controlled, open-label, crossover study
  

  Presenting Author: Spero Cataland, MD (he/him/his) – Department of Internal Medicine, Ohio State University, Columbus, OH, USA

  Co-Author: Munjal Patel – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Björn Mellgård – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Thomas L Ortel – Duke University, Durham, NC, USA

  Co-Author: Marie Scully, MD – Department of Haematology, University College London Hospitals, London, UK

  Co-Author: Linda T Wang – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Jerzy Windyga, Prof. dr med. (he/him/his) – Institute of Hematology and Transfusion Medicine

  Co-Author: Indranil Bhattacharya – Takeda Development Center Americas, Inc., Cambridge, MA, USA
• 11:15 – 11:30 ET

  A novel strategy to combat the procoagulant phenotype in immune thrombotic thrombocytopenia using 12-LOX inhibition
  

  Presenting Author: James V. Michael, PhD – Thomas Jefferson University

  Co-Author: Stephanie A. Renna – Thomas Jefferson University

  Co-Author: Xuefei Zhao, MS – Thomas Jefferson University

  Co-Author: Satya P. Kunapuli, PhD – Temple University

  Co-Author: Peisong Ma, PhD – Thomas Jefferson University

  Co-Author: Michael Holinstat, PhD – University of Michigan

  Co-Author: Matthew B. Boxer – Veralox Therapeutics

  Co-Author: David J. Maloney – Veralox Therapeutics

  Co-Author: Steven E McKenzie, MD, PhD – Thomas Jefferson University
• 11:30 – 11:45 ET

  Recombinant ADAMTS13 prophylaxis in patients with congenital thrombotic thrombocytopenic purpura: interim analysis from phase 3b continuation study
  

  Presenting Author: Paul Coppo, MD, PhD (he/him/his) – National Reference Center for Thrombotic Microangiopathy, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris and Sorbonne – Université (AP-HP.6), Paris, France

  Co-Author: Parth Patwari – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Björn Mellgård – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Hong Li – Takeda Development Center Americas, Inc., Cambridge, MA, USA

  Co-Author: Marie Scully, MD – Department of Haematology, University College London Hospitals, London, UK

  Co-Author: Masanori Matsumoto – Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan

  Co-Author: Jerzy Windyga, Prof. dr med. (he/him/his) – Institute of Hematology and Transfusion Medicine

  Co-Author: Thomas L Ortel – Duke University, Durham, NC, USA

  Co-Author: Spero Cataland, MD (he/him/his) – Department of Internal Medicine, Ohio State University, Columbus, OH, USA

  Co-Author: Paul Knoebl, MD – Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Vienna, Austria

  Co-Author: Ziqiang Yu – National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China

  Co-Author: Linda T Wang – Takeda Development Center Americas, Inc., Cambridge, MA, USA
• 11:45 – 12:00 ET

  Plasma exchange-free management of immune thrombotic thrombocytopenic purpura: the Austrian-German experience
  

  Presenting Author: Lucas Kühne, MD (he/him/his) – Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

  Co-Author: Paul Knoebl, MD – Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Vienna, Austria

  Co-Author: Kathrin Eller – Division of Nephrology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria

  Co-Author: Veronika Buxhofer-Ausch – Department of Internal Medicine I with Hematology, Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinnen, Linz, Austria

  Co-Author: Paul T. Brinkkoetter – Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

  Co-Author: Linus A. Völker – Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany