OC 27 - Megakaryocyte Biology

Moderator(s)

• 

  Genevieve Pepin, PhD, MBA

  Associate professor
  Université Du Québec à Trois-RIvières
  Trois-Rivieres, Quebec, Canada
• 

  Robert Campbell, PhD

  Professor
  University of Utah, Salt Lake City, UT, USA; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
  Salt Lake City, Utah, United States

Presentations:

• 14:45 – 15:00 ET

  Kupffer cells are required for platelet-mediated hepatocellular TPO generation
  

  Presenting Author: Danielle Karakas (she/her/hers) – Department of Laboratory Medicine and Pathobiology, University of Toronto

  Co-Author: June Li – Department of Laboratory Medicine and Pathobiology, University of Toronto

  Co-Author: Wenjing Ma – Keenan Research Centre, St. Michael's Hospital

  Co-Author: Mina Masoud – Department of Laboratory Medicine and Pathobiology, University of Toronto

  Co-Author: Chuanbin Shen – Keenan Research Centre, St. Michael's Hospital

  Co-Author: Sonya MacParland – University of Toronto

  Co-Author: Walter HA Kahr, MD, PhD (he/him/his) – Professor Departments of Paediatrics & Biochemistry, University of Toronto

  Co-Author: Heyu Ni, MD, PhD – Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
• 15:00 – 15:15 ET

  Mechanistic studies of runt-related transcription factor-1 (RUNX1)-deficient megakaryopoiesis and its correction by RepSox (RS), a TGFβ-receptor-1 inhibitor
  

  Presenting Author: Kiwon Lee, PhD (he/him/his) – Division of Hematology, Children's Hospital of Philadelphia

  Co-Author: Michael Gonzalez – The Center for Cytokine Storm Treatment and Laboratory, University of Pennsylvania

  Co-Author: Mortimer Poncz – Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
• 15:15 – 15:30 ET

  Single-cell transcriptomics reveal critical roles of G6b-B in regulating the megakaryocyte maturation
  

  Presenting Author: Maximilian Englert, MSc – Institute of Experimental Biomedicine - Chair I, University Hospital Würzburg and Rudolf Virchow Center for Integrative and Translational Biomaging, University of Würzburg, Germany

  Co-Author: Bernhard Nieswandt – Institute of Experimental Biomedicine - Chair I, University Hospital Würzburg and Rudolf Virchow Center for Integrative and Translational Biomaging, University of Würzburg, Germany

  Co-Author: Zoltan Nagy – Institute of Experimental Biomedicine - Chair I, University Hospital Würzburg and Rudolf Virchow Center for Integrative and Translational Biomaging, University of Würzburg, Germany
• 15:30 – 15:45 ET

  ZFPM2 regulates megakaryocyte proliferation, differentiation and granulogenesis and influences thrombotic risk
  

  Presenting Author: Kate L. Burley, MBChB (she/her/hers) – University of Bristol

  Co-Author: Amber Knapp-Wilson – University of Bristol

  Co-Author: Sarah Westbury – University of Bristol

  Co-Author: Parsa Akbari – Regeneron Pharmaceuticals Inc

  Co-Author: Luca Stefanucci – University of Cambridge

  Co-Author: William Astle – University of Cambridge

  Co-Author: Mattia Frontini – University of Exeter

  Co-Author: Andrew Mumford – University of Bristol
• 15:45 – 16:00 ET

  Single-cell RNA-Seq reveals age-dependent Mfsd2b expression in megakaryocyte progenitors that regulates thrombosis
  

  Presenting Author: Seyed Soheil Saeedi Saravi, PharmD, PhD (he/him/his) – Center for Translational and Experimental Cardiology (CTEC), University Hospital Zurich, University of Zurich

  Co-Author: Meret Allemann – Center for Molecular Cardiology, University of Zurich

  Co-Author: Pratintip Lee – Center for Molecular Cardiology, University of Zurich

  Co-Author: Wenfei Sun – Institute of Food, Nutrition and Health, ETH Zurich

  Co-Author: Tongtong Wang – Institute of Food, Nutrition and Health, ETH Zurich

  Co-Author: Hua Dong – Institute of Food, Nutrition and Health, ETH Zurich

  Co-Author: Christian Wolfrum – Institute of Food, Nutrition and Health, ETH Zurich

  Co-Author: Jürg Hans Beer – Department of Internal Medicine, Cantonal Hospital Baden