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    Oral Communication

    Venous Thromboembolism
    Oral Communication Session

    OC 17 - Genetics of Venous Thromboembolism

    Sunday, June 25, 2023
    10:45 – 12:00 ET
    Room:524

    Session Available Online As: On-Demand

    Presentations:

    • 10:45 – 11:00 ET
      The association between venous thrombosis-associated genetic variants and coagulation factor levels and thrombin generation potential

      Presenting Author: Jihee Han, MS – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

      Co-Author: Ruifang Li-Gao, PhD (she/her/hers) – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

      Co-Author: Renée de Mutsert – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

      Co-Author: Frits R. R. Rosendaal – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

      Co-Author: Astrid van Hylckama Vlieg, PhD – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

    • 11:00 – 11:15 ET
      New insights on the genetics of venous thromboembolism recurrence from a GWAS analysis of 6,504 patients including 1,797 recurrent events

      Presenting Author: Gaëlle Munsch, PhD – Inserm U1219 Bordeaux Population Health Research Center, University of Bordeaux

      Co-Author: Jennifer A. Brody – Department of Medicine, University of Washington, Seattle WA, USA.

      Co-Author: Astrid van Hylckama Vlieg, PhD – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

      Co-Author: Florian Thibord, PhD – Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA.

      Co-Author: France Gagnon – Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

      Co-Author: Lénaïck Gourhant – Department of internal medicine and chest diseases, INSERM U1304_GETBO, Univ_Brest, CHU_Brest, Brest, France

      Co-Author: Louisa Goumidi – Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique – Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France.

      Co-Author: Marine Germain – University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219, Bordeaux, France.

      Co-Author: Anne Boland – Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.

      Co-Author: Jean-François Deleuze – Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.

      Co-Author: Hélène Jacqmin-Gadda – University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219, Bordeaux, France.

      Co-Author: Nicholas L. Smith – Department of Epidemiology, School of Public Health, University of Washington

      Co-Author: Frits R. R. Rosendaal – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

      Co-Author: Andrew D. D. Johnson, PhD (he/him/his) – Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA.

      Co-Author: Marc A. Rodger, MD (he/him/his) – Department of Medicine, McGill University, McGill University Health Center, Montreal, Quebec, Canada

      Co-Author: Francis Couturaud, PhD (he/him/his) – Centre Hospitalo-Universitaire de Brest, Département de Médecine Interne et Pneumologie, INSERM U1304, CIC INSERM 1412, Univ_Brest, Brest, FCRIN INNOVTE, France.

      Co-Author: Pierre-Emmanuel Morange, MD, PhD – Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, Hôpitaux de Marseille, Marseille, France

      Co-Author: David-Alexandre TREGOUET, PhD (he/him/his) – Bordeaux Population Health research center - INSERM UMR1219

    • 11:15 – 11:30 ET
      Prothrombotic polymorphisms FV Leiden and prothrombin G20210A in 699 unrelated patients with congenital antithrombin deficiency: more than a prognostic value

      Presenting Author: Carlos Bravo Perez, MD, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER, Murcia, Spain

      Co-Author: Christelle Orlando, PhD – Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of laboratory haematology, Laarbeeklaan 101, 1090 Brussels, Belgium.

      Co-Author: Réka Gindele – Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

      Co-Author: Rosa Cifuentes – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER, Murcia, Spain

      Co-Author: Katrien Stouffs – Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of medical genetics, Laarbeeklaan 101, 1090 Brussels, Belgium.

      Co-Author: Péter Ilonczai – Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen. Hungary

      Co-Author: Maria Eugenia de la Morena-Barrio, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Murcia, Spain

      Co-Author: Ágota Schlammadinger – Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen. Hungary

      Co-Author: György Pfliegler – Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen. Hungary

      Co-Author: Javier Corral, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER, Murcia, Spain

      Co-Author: Kristin Jochmans – Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of laboratory haematology, Laarbeeklaan 101, 1090 Brussels, Belgium.

      Co-Author: Zsuzsanna Bereczky, MD, PhD (she/her/hers) – Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

    • 11:30 – 11:45 ET
      Determining the Risk of Thrombosis in Double Heterozygous Carriers of Factor V Leiden and Prothrombin G20210A Mutation Using Population-Scale Genomics

      Presenting Author: Justine Ryu, MD – Beth Israel Deaconess Medical Center

      Co-Author: Sean Jurgens – Broad Institute of MIT and Harvard, Cambridge, MA

      Co-Author: Seung Hoan Choi – Broad Institute of MIT and Harvard, Cambridge, MA

      Co-Author: Satoshi Koyama – Broad Institute of MIT and Harvard

      Co-Author: Patrick Ellinor – Massachusetts General Hospital

      Co-Author: Steven Lubitz – Novartis Institutes for Biomedical Research

      Co-Author: Kenneth Bauer – Beth Israel Deaconess Medical Center

      Co-Author: Pavan K. Bendapudi – Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

    • 11:45 – 12:00 ET
      Genetic association of the 4q34.1 locus with residual vascular obstruction in patients with pulmonary embolism

      Presenting Author: Floriane Samaria (she/her/hers) – Bordeaux Population Health research center - INSERM UMR1219

      Co-Author: Gaëlle Munsch, PhD – Inserm U1219 Bordeaux Population Health Research Center, University of Bordeaux

      Co-Author: Lénaïck Gourhant – Department of internal medicine and chest diseases, INSERM U1304_GETBO, Univ_Brest, CHU_Brest, Brest, France

      Co-Author: Catherine A. Lemarie, PhD – Department of internal medicine and chest diseases, INSERM U1304_GETBO, Univ_Brest, CHU_Brest, Brest, France

      Co-Author: Marine Germain – University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219, Bordeaux, France.

      Co-Author: Anne Boland – Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH)

      Co-Author: Jean-François Deleuze – Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH)

      Co-Author: David-Alexandre TREGOUET, PhD (he/him/his) – Bordeaux Population Health research center - INSERM UMR1219

      Co-Author: Francis Couturaud, PhD (he/him/his) – Centre Hospitalo-Universitaire de Brest, Département de Médecine Interne et Pneumologie, INSERM U1304, CIC INSERM 1412, Univ_Brest, Brest, FCRIN INNOVTE, France.