PB0134 - Use case scenarios for a portable near-patient hemophilia A testing device

Background: To improve the diagnosis and management of patients with hemophilia A, a portable near-patient testing (NPT) multi-parameter blood coagulation analysis system (EnzySystem) is being developed. It measures Factor VIII activity, thrombin generation and internal controls simultaneously in 100 µl of capillary whole blood within one hour.

Aims: Identify use case scenarios for the EnzySystem for the diagnosis and monitoring of patients with hemophilia A and survey the interest for a small and painless capillary blood collection device able to draw only tiny amounts of citrated whole blood (100 µl).

Methods: Use-case analysis was performed with healthcare professionals and patients with hemophilia A to determine their use-case preferences regarding such a NPT device. Data was acquired using (online) interviews with patients and healthcare professionals.

Results: For this interim analysis, data of 19 healthcare professionals and 3 patients who participated in the questionnaire were analyzed. Most respondents (58%) were enthusiastic and 74% of the healthcare professionals would consider the NPT device in their daily routine. Both near-patient use (49%) and home-use (42%) were identified as attractive markets, whereas the interest for in-clinic use (27%) is limited (Figure 1).
Moreover, respondents showed high interest in an alternative blood draw method (76%, Figure 2) which should be compatible with the NPT device. Compared to the conventional venipuncture, the alternative method enables patients to independently draw blood in a home environment.

Conclusion(s): Interim data analysis showed that healthcare professionals and patients would consider using a NPT device, especially in near-patient and home-use situations. The coming months more data will be gathered to draw firm conclusions about the different use cases for the NPT device.