PB0101 - Comparison of Padua Prediction Score and IMPROVE VTE Risk Score for Venous Thromboembolism at Admission to Assess Hypercoagulation in COVID-19 Patients

Sunday, June 25, 2023

18:30 – 19:30 ET

Room: Exhibition

Presenting Author(s)

PL

Pearla Fidei Cindy Lasut

Hematologist - Oncologist (Internist)
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia

Co-Author(s)

AH

Andrew Orlando Easterio Hukom

Internist
Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia
Visakha Revana Irawan, MD

Internal Medicine Resident
Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia
JA

Jonathan Arifputra

Internal Medicine Resident
Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia
LR

Linda Wilhelma Ancella Rotty

Hematologist - Oncologist (Internist)
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia
HH

Harlinda Haroen

Hematologist - Oncologist (Internist)
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia
CH

Cecilia Andalina Hendratta

Hematologist - Oncologist (Internist)
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University / Prof. dr. R. D. Kandou General Hospital, Manado, Indonesia
Manado, Sulawesi Utara, Indonesia

Background: The inflammatory process, cytokine storm, and lung injury associated with the Coronavirus disease 2019 (COVID-19) can increase the risk of venous thromboembolism (VTE). Once VTE is complicated with COVID-19, the treatment will be challenging, and the patients may have a worse clinical outcome. Padua Prediction Score (PPS) and IMPROVE VTE Risk Score (IVRS) are validated tools for VTE risk assessment.

Aims: We aimed to compare these two validated tools to assess hypercoagulation in COVID-19 patients.

Methods: A cross-sectional retrospective study was conducted on COVID-19 patients. We enrolled adult patients who were hospitalized in Prof. dr. R. D. Kandou General Hospital from August 2022 to October 2022. D-dimer levels and data of VTE risk assessment using PPS and IVRS were collected at admission and analyzed to determine the hypercoagulation state. A D-dimer level above two is considered a hypercoagulation state. Data analyses were done using SPSS version 22.

Results: A total of 42 COVID-19 patients were included in this study. There were 23 patients (54.76%) having elevation of D-dimer (> 2 µg/mL). Mean of PPS and IVRS, consecutively, was 1.48 ± 1.93 and 1.07 ± 1.20. Therefore, PPS was not superior than IVRS to assess hypercoagulation in COVID-19 patients [AUC 0.754 (0.078); p= 0.005 vs. AUC 0.759 (0.077); p=0.004]. Combination the values of PPS and IVRS was more superior to assesses hypercoagulation [AUC 0.815 (0.072); p=0.001].

Conclusion(s): Padua Prediction Score and IMPROVE VTE Risk Score can be used to assess hypercoagulation in COVID-19 patients. In addition, the combination of these two validated tools is superior to assess hypercoagulation in COVID-19 patients.