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    Poster Networking

    COVID

    Poster Networking Session

    PB0081 - Von Willebrand factor and myeloperoxidase as laboratory predictive markers of in-hospital survival in severe COVID-19 patients

    Sunday, June 25, 2023
    18:30 – 19:30 ET
    Room: Exhibition

      Presenting Author(s)

    • AM

      Alexander Makatsariya

      Head of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

      • Co-Author(s)

    • VB

      Victoria Bitsadze

      Professor of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • Jamilya Khizroeva, MD

      Professor of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • LP

      Liudmila Pankratyeva

      Professor of Obstetrics, gynecology and perinatal medicine
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • Jean-Christophe R. Gris, MD, PhD

      Professor
      Department of Hematology, CHU Nîmes, Univ Montpellier, Nîmes, France
      Nimes, Languedoc-Roussillon, France

    • IE

      Ismail Elalamy

      Director of Hematology Department of Thrombosis Center, Tenon University Hospital
      Medicine Sorbonne University
      Paris, Ile-de-France, France

    • MT

      Maria Tretyakova

      professor of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • GK

      Grigoreva Kristina

      Assistant of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • ZA

      Zamilya Aslanova

      Postgraduate student of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • Nilufar Gashimova, Postgraduate

      Postgraduate student of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • IN

      Inga Nakaidze

      Postgraduate student of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • DZ

      Diana Zabolotnaya

      Resident doctor of the Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • AP

      Anna Pervushina

      Resident doctor of the Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • DB

      David Blbulyan

      Resident doctor of the Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • AL

      Arina Lazarchuk

      Student of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    • PS

      Polina Salnikova

      Student of Obstetrics, gynecology and perinatal medicine Department
      I.M.Sechenov First Moscow State Medical University
      Moscow, Moskva, Russia

    Background: The severe COVID-19 highlighted the central role of immunothrombosis and severe endothelial damage with the release of unusually large multimers of von Willebrand factor (vWF) and subsequent consumption of ADAMTS-13. The activation of innate immune cells among which neutrophils contribute to the formation of extracellular neutrophil traps and to the release of myeloperoxidase (MPO) potentially contributing to the spread of inflammation and microvascular thrombosis.

    Aims: To evaluate the ability of vWF, ADAMTS-13 and MPO to predict in-hospital mortality in severe COVID-19 patients needing mechanical ventilation.

    Methods: We performed a one-center observational study of 79 severe COVID-19 patients entering intensive care unit for mechanical ventilation, examining vWF, ADAMTS-13 and MPO among other potential predictors for in-hospital death. Initially were screened 214 hospitalized COVID-19 ICU patients. Only 129 of them could be pre-included due to blood sample availability at admission, and among them 79 patients were included due to the availability of residual plasma samples for non-routine investigations (fig.1). Spearman's rank correlation was used for estimating the correlation between the parameters. We compared relevant variables and parameters between survivors and non-survivors.

    Results: After multivariate analysis, vWF antigen (vWF:Ag) and MPO antigen (MPO:Ag) were finally the single two parameters which increasing values were independently associated with non-survival; vWF:Ag (U/dL): adjusted OR 3.360, 95% CI 1.562-7.228, p=0.0019; MPO:Ag (ng/ml): adjusted OR 1.062, 95% CI 1.024-1.101, p= 0.0011 (table 1). From these results a simplified mortality score was derived and patients categorized as having a score value higher or lower that the median value of the score: a high score value was associated with a lower cumulative survival rate (p < 0.0001), 50% of the cases being dead at day 13 post-hospital admission.

    Conclusion(s): in severe COVID-19 necessitating mechanical ventilation, increasing values of MPO activity and of vWF antigen tested at admission are associated with a poor survival.