PB0068 - Pulmonary sequelae in Long COVID are not associated with the carriage of prothrombotic genetic variants.

Sunday, June 25, 2023

18:30 – 19:30 ET

Room: Exhibition

Presenting Author(s)

Gabriela F. de Larrañaga, PhD

Dr.
Hospital de Infecciosas F. J. Muñiz
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina

Co-Author(s)

PR

Pamela Rossi

Dr.
Hospital Donación Santojanni
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
FT

Florencia Trullas

Dr
Hospital General de Agudos J. M. Ramos Mejía
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
VB

Valeria Brichetti

Dr
Hospital Donación Santojanni
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
SP

Silvia Perés

Dr
Hospital de Infecciosas F. J. Muñiz
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
Federico Aranda

Dr
Hospital de Infecciosas F. J. Muñiz
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
PM

Priscila Montesinos

Lic.
Hospital Donación Santojanni
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
TR

Tamara Rubilar

Dr
Laboratorio de Química de Organismos Marinos, Instituto Patagónico del Mar, Universidad Nacional de la Patagonia San Juan Bosco (UNPSJB) and CESIMAR-CONICET
Puerto Madryn, Chubut, Argentina
AC

Augusto Crespi

Dr.
Laboratorio de Química de Organismos Marinos, Instituto Patagónico del Mar, Universidad Nacional de la Patagonia San Juan Bosco (UNPSJB) and CESIMAR-CONICET
Puerto Madryn, Chubut, Argentina
AM

Alejandro Martinez Fraga

Dr.
Hospital Médico Policial Churruca Visca
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
MS

Martín Sívori

Dr.
Hospital General de Agudos J. M. Ramos Mejía
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
FS

Fernando Saldarini

Dr.
Hospital Donación Santojanni
Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina

Background: Up to 30% of the infected subjects during coronavirus 19 disease (COVID-19) suffers from long term COVID symptoms, known as Long COVID. Patients with moderate and severe COVID-19 pneumonia shows "fibrotic like" pattern in the tomography after 6 months and it is related to worse lung functional evolution. SARS-CoV-2 infection can provoke dysregulation of urokinase, coagulation, and fibrinolysis pathways contributing to the severity of the lung injury, possibly through altering the hemostatic balance with subsequent coagulation-induced ischemic injury. Moreover, an increased thrombin activation is known to induce endothelial barrier disruption thus promoting fibrin deposition and injuries in the lungs. It may be hypothesized that prothrombotic genetic variants in proteins of the coagulation cascade may be involved in the development of lung sequelae in Long COVID (Image 1).

Aims: To assess the association between the carriage of prothrombotic genetic variants and having pulmonary sequelae in Long COVID.

Methods: We strictly selected 38 subjects who developed moderate or severe SARS-CoV-2 pneumonia, all of them confirmed by PCR or antigen tests, and after 3 months of the discharge continued with symptoms and tomographic lung compromise. We analyzed the genotypic distributions of the genetic variants Factor V Leiden, Factor II20210A, Fibrinogen Gamma 10034C>T and Factor XI 7872C>T and compared them with those from a group of 252 subjects of general population (blood donors). Differences in genotypic distributions were studied by a Chi-square test.

Results: Table 1 shows the genotypic distributions of the genetic variants studied between both groups.

Conclusion(s): No association was found between the carriage of any of the prothrombotic genetic variants and a higher risk of developing pulmonary sequelae. Therefore, the origin of the lung COVID- 19 sequelae is not related to a prothrombotic genetic variant making even more important to keep researching the causes of the sequelae to understand it more clearly.