PO17 - Impact of Bleeding complications and Joint Disease On quality Of life of patients with severe haemophilia A: A case study of Kenyatta National Hospital haemophilia Clinic.

Background: Joint disease is caused by bleeding in joints leading to joint stiffness causing suffering in Haemophilia. Bleeding has devastating effects on joint components, resulting in sinusitis, bone degeneration and end-stage joint disease. Many adults grew up without treating bleeds early and adequate factor, resulting in target joints or joint disease. Joint disease affect patients physically and emotionally; mainly gait, physical abilities, body image, feeling of vulnerability, and time loss from school and work.
Joint disease is debilitating and causes morbidity. Despite improved quality of care and factor concentrates, joint disease causes inflammation and synovial hypertrophy leading to difficult experience like: mobility problems, unexplained bleeding, and pain (Rodriguez-Merchan EC 2018) This study has not been done in KNH and even Kenya.

Aims: This research will establishing extent to which joint disease and bleed complications affect QOL in severe HA. Establishing specific ways the patients are affected, well informed strategies can be formulated to mitigate/minimize the effects.

Methods: Study will be done at Kenyatta National hospital Haemophilia clinic. Participants being severe HA patients, attending KNH Clinic, with joint disease and bleed complications, enrolled after consenting.
Clinic has 120 severe HA patients. Random sampling method employed to obtain 50% of patients as the sample. Quantitative random sampling technique will be used. Data collection by User-administered questionnaire, analyzed by SPSS application and findings disseminated to relevant people.

Results: Study results will highlight specific ways severe HA affects patients' QOL. Presentation will be in tables, chats and different types of graphs forms.

Conclusion(s): Study will find out impact of joint disease and bleed complication on QOL of severe HA . Prevention and effective target joints treatment is important to clinicians and patients managing haemophilia. Survey will demonstrate if severe HA with other bleed complications will cause impaired HRQoL, despite standard treatment, and other effective treatment options will be needed.