PO07 - Is Covid-19 a trigger factor for thrombotic complications in late pregnancy?

Background: A pandemic caused by the new SARS-Cov2 virus began in December 2019, putting pressure on global medical systems. Pregnancy has been proven to make one more vulnerable to a more severe and critical form of COVID-19, which can lead to an increased rate of premature birth, premature rupture of membranes, or cesarean section.

Aims: The main objective of this study was to identify several peculiarities regarding the evolution of COVID-19 complications when diagnosed in pregnant women during the third trimester.

Methods: The study was done retrospectively and included 3 patients.

Results: Case 1 involves a 38-year-old woman who became SARS-Cov2 positive in week 38 of pregnancy with a mild form of COVID-19, but as it evolved it presented uncertain foetal status, identified as oligoamnios, therefore a caesarean section was required 13 days after the onset of COVID-19 symptoms. Case 2 involves a 42-year-old woman who became SARS-Cov2 positive during week 35 of pregnancy, and whose symptoms evolved critically (acute hypoxemic respiratory failure with acute foetal hypoxia) and who was diagnosed 11 days after the onset emergency caesarean section was performed. Case 3 involves a 44-year-old woman who was diagnosed as being SARS-Cov2 positive in week 33 of pregnancy, 12 days from the onset of symptoms. Symptoms included acute hypoxemic respiratory failure accompanied by foetal distress; an emergency caesarean operation was performed. All patients developed severe thrombotic complications as COVID-19 symptoms developed.

Conclusion(s): COVID-19 in pregnant women may lead to a severe form of the virus and may have severe thrombotic complications and procoagulant status. A broader analysis of the effect of SARS-Cov2 in pregnancy is needed on a larger number of patients including patients with mild to moderate COVID-19.