PB0637 - Epidemiological, clinical and radiological profile of articular pathology (joint disease) in the Cameroonian haemophiliac

Monday, June 26, 2023

18:30 – 19:30 ET

Room: Exhibition

Presenting Author(s)

AN

ANNICK NDOUMBA NKENGUE, MD

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Cameroon Hemophilia Treatment Centre, Department of Hematology and Blood Transfusion, Yaoundé University Teaching Hospital
Yaoundé, Centre, Cameroon

Co-Author(s)

MN

MICHAEL NKO'O AMVENE

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Yaounde, Centre, Cameroon
DH

DANIEL HANDY EONE

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Department of surgery, Yaounde Central Hospital, Cameroon
Yaounde, Centre, Cameroon
EM

ERIC MAGNY TIAM

Department of radiology, Yaoundé University Teaching Hospital
Department of radiology, Yaoundé University Teaching Hospital
Yaounde, Centre, Cameroon
CT

CLAUDE TAYOU

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Cameroon Hemophilia Treatment Centre, Department of Hematology and Blood Transfusion, Yaoundé University Teaching Hospital
Yaounde, Centre, Cameroon
PO

PIERRE ONGOLO ZOGO

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Department of radiology, Yaounde Central Hospital, Cameroon
Yaounde, Centre, Cameroon
DM

DORA MBANYA

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
Cameroon Hemophilia Treatment Centre, Department of Hematology and Blood Transfusion, Yaoundé University Teaching Hospital
Yaounde, Centre, Cameroon

Background: People with hemophilia (PWH) in Cameroon have little financial means to support themselves. Most patients did not have access to clotting factors until the intervention of Humanitarian Aid program of the World Federation of Hemophilia (WFH). Chronic arthropathies are common but there is no research on joint disease. Through a grant from the Research Support Program (RSP) of WFH World Bleeding Disorders Registry (WBDR), the Cameroon Hemophilia Treatment Centre (HTC) is able to study the profile of joint disease of the Cameroonian PWH.

Aims: The research aims to study the epidemiological, clinical and radiological profile of joint disease in PWH in Cameroon.

Methods: In a cross-sectional study conducted from December 2020 to March 2022 at the Cameroon HTC, we assessed PWH using Hemophilia Joint Health Score (HJHS) tool and entered the data in the WBDR. We also performed radiological and ultrasound of elbows, knees and ankles. The data were analysed using MS Excel 2013 and CS Pro 7.3.

Results: Of the 38 PWHs, there were 34 hemophilia A (89,47%) and 29 severe hemophilia (76,31%). The average age of the PWH is 16 years old, range 3-42 years. We examined 228 joints. From HJHS, 32 PWHs (84%) have damaged joints. The most affected was knees (43%) followed by elbows and ankles. From radiographic findings, 152/228 (67%) joints are pathologically affected, 64 (42%) are knees. At 55% (125/228), an enlargement of epiphysis is the most frequent lesion. From the ultrasound results, 82/228 (36%) joints are pathologically impacted, 37 (45%) are knees. The ultrasound also shown that 45.2% of joints (103/228) had hemosiderin deposition.

Conclusion(s): This is the first study that collects and analyzes the profile of joint disease in the Cameroonian PWH. The degree of joint damage in PWH in Cameroon is considerable and is a direct result of sub-optimal treatment for patients.