PB0586 - Protein S deficiency is Associated with an Increased Risk of Deep Vein Thrombosis in Pregnant Women Using Oral Contraceptive

Monday, June 26, 2023

18:30 – 19:30 ET

Room: Exhibition

Presenting Author(s)

Abdulrahman Algarni, PhD

Assistant professor
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar P.O. Box 91431, Saudi Arabia
Arar, Al Hudud ash Shamaliyah, Saudi Arabia

Co-Author(s)

EA

Ezeldine K. Abdalhabib

Assistant professor
Ezeldine K Abdalhabib Department of Clinical Laboratory Sciences, College of Applied Medical Sciences-Al Qurayyat, Jouf University, Sakaka, Saudi Arabia
Al Qurayyat, Al Jawf, Saudi Arabia

Background: Deep Vein Thrombosis (DVT) causes high morbidity and mortality rates among patients, affecting women especially those that use oral contraceptives and are pregnant because of Protein S deficiency. The purpose of Protein S in the body is to regulate thrombin generation. Protein S and DVT in pregnant women are a global concern.

Aims: The study aims to determine the influence of Protein S deficiency on high DVT levels among pregnant women and women using oral contraceptives.

Methods: A case-control study design was utilized to assess the influence of Protein S deficiency on high DVT levels among pregnant women and women using oral contraceptives between June 2019 and August 2022 and residing in the Sudanese community. One hundred and sixty-five study participants with DVT and taking oral contraceptives were recruited together with 165 control participants. Blood samples, demographic and genetic and lifestyle predisposing factors to DVT were collected using questionnaires. The natural inhibitors PC, PS and AT were also measured in patients and cases.

Results: Among the DVT cases, 18.9% had Protein S deficiency, 22.4% had AT deficiency, and 3.6% had PC deficiency, as illustrated by table 1 below. The participants’ PS deficiency differences were statistically significant (p = 0.002). Additionally, there was a statistically significant difference in blood levels of Protein S, protein C and antithrombin, and it was lower in the cases as compared to controls, as shown in Table 2. Deficiency in blood levels of PC, PS and AT was high in women who were taking third-generation oral contraceptives. Also, there was a significant difference in the means of coagulation profiles between the cases and controls. The cases had significantly higher mean of prothrombin time (PT) and international normalized ratio (INR) levels compared to the controls.

Conclusion(s): Pregnant women using oral contraceptives recorded Protein S deficiency, a DVT risk factor.