PB0573 - Routine haemostasis profile in sickle cell disease patients in steady state: a retrospective, descriptive study

Monday, June 26, 2023

18:30 – 19:30 ET

Room: Exhibition

Co-Author(s)

Comlan Louis AFFO, MD

DMU ESPRIT, Service de médecine interne, Hôpital Louis Mourier, Colombes
Assistance-Publique–Hôpitaux de Paris (AP-HP), Université Paris Cité
Colombes, Ile-de-France, France

Co-Author(s)

CS

Carine SCHMIDT

DMU ESPRIT, Service de médecine interne, Hôpital Louis Mourier, Colombes
Assistance-Publique–Hôpitaux de Paris (AP-HP), Université Paris Cité
Colombes, Ile-de-France, France
AB

Antoine BOSQUET

DMU ESPRIT, Service de médecine interne, Hôpital Louis Mourier, Colombes
Assistance-Publique–Hôpitaux de Paris (AP-HP), Université Paris Cité
Colombes, Ile-de-France, France
BD

Benedicte DUMONT

Service d'hématologie biologique et transfusion
Assistance-Publique–Hôpitaux de Paris (AP-HP), Université Paris Cité
Colombes, Ile-de-France, France

Presenting Author(s)

Isabelle MAHE, MD, PhD (she/her/hers)

MD,PhD
Paris Cité University, APHP, Hôpital Louis Mourier, Colombes, Internal Medicine Department, INSERM UMR_S1140, and F-CRIN InnoVTE, France
Colombes, Ile-de-France, France

Background: Sickle cell disease (SCD) is a genetic disease resulting from an abnormality in hemoglobin. Haemostasis in steady state is poorly described. Steady state is defined by a period of at least 2 months without vaso-occlusive crisis (VOC). Few studies of small numbers are reported. No study of haemostasis parameters during pregnancy is available.

Aims: Our study aims to describe routine haemostasis profile (PT, APTT, platelets) in steady state in sickle cell patients during pregnancy or not, according to their phenotype.

Methods: Retrospective study over 11 years (2010 to 2021) includes patients with SCD aged from 18 and more. Routine haemostasis parameters were collected from medical records. For each parameter, the values are compared to laboratory norms and the SS phenotype group is compared to the SC, SB°Thal and SB+Thal phenotype groups. The statistical significance was assumed at a p value of less than 0.05.

Results: 119 patients had checkups representing 190 day hospitals. We excluded 15 day hospitals in 7 patients treated with anticoagulant. Of the 112 patients included, 11 patients were pregnant. The mean values of the routine hemostasis parameters are within normal values whether during pregnancy or not. The mean PT is lower during pregnancy (12.3 ± 0.6 sec vs 13.2 ± 1.0 sec., p = 0.01). PT and platelet count are higher (13.9 ± 1.0 sec. vs 12.6 ± 0.9 sec., p = 0.01; 385.5 ± 124.7 G/L vs 269 ± 112.2 G/L, p = 0.03) and APTT lower (1.09 ± 0.14 vs 1.18 ± 0.13, p < 0.001) in SS group without pregnancy, compared to the values in SC group.

Conclusion(s): For the first time, parameters of haemostasis in pregnant patients with SCD were described.This study will serve as a basis for a cohort study with more coagulation parameters in steady state and during acute complications of SCD.