PB0335 - Medical Education in Congenital Thrombotic Thrombocytopenic Purpura Significantly Improves Competence in Making Appropriate Management Choices

Background: Guidelines on the management of congenital thrombotic thrombocytopenic purpura (cTTP) are vague due to the paucity of existing data, and therefore management approaches are inconsistent. Clinicians need expert evidence-based guidance on how to manage patients with cTTP throughout the disease continuum, from the initial diagnosis, to refractory situations, to managing sub-acute symptoms between acute phases, and preventing long-term complications.

Aims: We sought to improve physician competence in implementing appropriate management strategies for patients with cTTP by providing expert-led case-based education.

Methods: Physicians participated in a 32-minute, video-based, online CME activity divided into 4 case-based discussions with different speakers and synchronized slides.1 The effects of the education were assessed using a 3-question, repeated pairs, pre-assessment/post-assessment study design. One question assessed confidence. Differences from pre- to post-assessment were evaluated as described in the figure. The activities launched in August 2022 and, and data were collected through November 2022.

Results: Overall significant improvements were seen after participation for both hematologists (average correct response rate of 49% at pre-assessment vs 70% at post-assessment; P<.001, Cohen’s d= 0.80, N=72), and emergency medicine (EM) physicians (average correct response rate of 34% at pre-assessment vs 57% at post-assessment; P<.001, Cohen’s d= 0.58, N=119). Specifically, significant improvements were observed in clinicians’ ability to selecting the right treatment in the context of pregnancy-onset cTTP, of subacute symptoms of cTTP, and of a history of ischemic stroke with cTTP (figure).
After participating in the activity, 51% of hematologists and 52% of EM physicians had measurable improved confidence related to selecting appropriate management strategies for patients with cTTP throughout the disease course.

Conclusion(s): This study demonstrates the success of online, multi-component, multi-faculty, video-based education in improving competence and confidence in managing different types of clinical scenarios in cTTP.