PB1269 - Comorbidities - an additional burden in the real life of patients with haemophilia

Tuesday, June 27, 2023

18:30 – 19:30 ET

Room: Exhibition

Presenting Author(s)

Cristina E. Ursu (she/her/hers)

MD, PhD
Onco-Hematology Research Unit, Romanian Academy of Medical Sciences, Children Emergency Hospital “Louis Turcanu” Timisoara, European Hemophilia Treatment Centre, 300011 Timisoara, Romania
Timisoara, Timis, Romania

Co-Author(s)

MS

Margit Serban

Professor Doctor
Onco-Hematology Research Unit, Romanian Academy of Medical Sciences, Children Emergency Hospital “Louis Turcanu” Timisoara, European Hemophilia Treatment Centre, 300011 Timisoara, Romania
Timisoara, Timis, Romania
PS

Petre Serban

Quality Manager, PhD
Medical Centre for Education and Rehabilitation of Children and Young Adults, European Hemophilia Treatment Centre, 305100 Buzias, Romania
Buzias, Timis, Romania
AT

Adina Traila

MD
Medical Centre for Education and Rehabilitation of Children and Young Adults, European Hemophilia Treatment Centre, 305100 Buzias, Romania
Buzias, Timis, Romania
DA

Daniel Andrei

President of the Romanian Hemophilia Association
Romanian Hemophilia Association
Timisoara, Timis, Romania
IV

Ines Vaide

MD, PhD student
Department of Hemato-Oncology, Institute of Clinical Medicine, University of Tartu, Estonia
Tartu, Tartumaa, Estonia
CJ

Cristian Jinca

MD, PhD
Department of Pediatrics, Division of Onco-Hematology, “ Victor Babes ” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Timisoara, Timis, Romania
EB

Estera Boeriu

MD, PhD
Department of Pediatrics, Division of Onco-Hematology, “ Victor Babes ” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Timisoara, Timis, Romania
TA

Teodora Smaranda Arghirescu, MD, PhD

MD, PhD, Associate Professor
Department of Pediatrics, Division of Onco-Hematology, “ Victor Babes ” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Timisoara, Timis, Romania

Background: In a world without adequate therapy, haemophilia-related morbidity presents a deleterious impact on the quality of life of persons with hemophilia (PwH). Hemophilia-independent comorbidities are certainly increasing the burden of disease.

Aims: Our objective was to analyze the dimension and profile of comorbidities in PwH, in terms of epidemiological evaluation, cumulative assessment of concomitant diseases, and severity.

Methods: Our cross-sectional observational survey was conducted on a group of 122 PwH over a period of three years (2019-2021), divided according to the age of birth (after and prior to the introduction of the National Haemophilia Program-related therapy), in group 1 ( < 23 years, 11.91±6.82) and group 2 (˃ 23 years, 40±10.69). The epidemiological and cumulative assessment and severity of concomitant diseases were realized by establishing 14 disease-researched areas, evaluating their severity, and calculating the cumulative illness rating scale (CIRS).

Results: Patients in group 1 had only one comorbidity, underweight being present in 33.3% of cases. The patients in the 2nd group were overweighed in 33,73%, with obesity in 21.68% of cases; cardiovascular comorbidities affected 26,5%, arterial hypertension ranking first (10.84%); osteoporosis was recorded at 15.66%, diabetes, epilepsy, chronic hepatitis, kidney failure, and psoriasis affecting 1,2-2,4% of them. The cumulative prevalence of comorbidities was impressive, with an evocative CIRS index of 373 in group 2, and 64 in group 1. Surgical interventions for comorbidities were needed in 5 (4,1%) of all patients, one (2,56%) from the first and 4 (4,82%) from the second group.

Conclusion(s): Comorbidities dependent on the age of PwH (r=0.66), unfortunately, started to develop early in adulthood, presenting a multidisciplinary profile. A comprehensive approach with specialists in other fields (cardiology, oncology, psychiatry) is mandatory to provide optimal care for PwH.