PB0249 - Some Coagulation profiles (PT, APTT, TT, FIB), Red Cell, Total White Cell, Platelet Counts and their Indices Activity Levels in Persons Exposed to Wood Smoke (firewood) in Calabar, Nigeria

Background: Man used wood as the primary fuel for heating in the cold, lighting in the dark, and for cooking food. Prolonged exposure to wood smoke activates inflammation especially as it relates to respiratory system to increase it risk.

Aims: To reveal the changes associated with Rbc, Hb, Hct, TWBC, PLT, their indices, PT, APTT, TT and FIB on human subject exposed to wood smoke (firewood).

Methods: A convenient Cross-sectional study design using whole blood and citrated samples. 100 Subject of 50 Persons exposed, and 50 Persons NOT exposed to Wood Smoke (firewood), male and female of age range 15 - 62years. PT, APTT, TT was done using One-Stage Quick Clot-based method, FIB level was estimated based on Clauss technique; while Rbc, Hb, Hct, TWBC, PLT and their indices were determined using Haematology Analyzer. Statistics was done by using student’s t-test and analysis of variance by statistical software SPSS version 21.0.

Results: Hb, MCHC and FIB levels (127g/dL, 31.03%, 3.09g/l) of Persons exposed were significantly reduced while PDW, PT and TT levels (15.08fl, 16.4secs, 16.4secs) were raised when compared with Persons NOT exposed to firewood (P < 0.05) table 1. TWBC shows no significant difference (P > 0.05) for subjects in this study. In duration (1-5, 6-10, 11-15, >16yr) of years exposed to firewood, PT, TT and FIB levels shows significant progressive increase (13.1, 15.2, 19.4, 20.7secs), (14.7, 14.6, 18.9, 20.1secs) and decrease (3.8, 3.5, 2.2, 2.1g/l) respectively as years increased (table 2).

Conclusion(s): There was a significantly change in Rbc, Hb, PDW, PT, APTT, TT and FIB of Persons exposed to Wood Smoke (firewood) in this study, especially in the duration of years exposed which shown a progressive increase (PT and TT) and decrease (FIB) trend. This may predispose them to DIC and other disease conditions apart from lung and respiratory diseases.