PB0248 - Changes in Some Coagulation Parameters of Single Women Using some Oral and Injectable Contraceptives in Calabar Metropolis, Cross River, Nigeria

Background: Women taking oral contraceptives appear to have ~3- to 4-fold increased risk of thrombosis.

Aims: To assess PT, APTT, TT and FIB of single women using some form of contraceptives in Calabar, Cross River State, Nigeria.

Methods: A cross-sectional descriptive study and a convenient well-filled questionnaire were used. Citrated sample was gotten from 198 female, grouped into 98 Single women on Contraceptive and 100 singles women not on contraceptive, of age range 15 – 30 years in Calabar, Cross River State, Nigeria. The single women were on oral 42.9% (Postinol 2) and Injectables 57.1% [Depo-Provera (64.3%) and Noristerat (35.7%)]. Quick’s one stage was used for PT, APTT and TT (Helena), while Clauss’s Method was used to assess Fibrinogen levels. Ethical Clearance was gotten.

Results: Mean ± SD of PT, FIB and TT (12.8secs, 2.7g/l and 12.61secs) was shown to be significantly slightly higher and reduced in single women on Contraceptive when compared to single not on contraceptive (12.3secs, 2.5g/l and 14.41secs) p < 0.05 respectively. Meanwhile, there was a statistically significant progressive increase in PT and FIB levels, while APTT and TT decrease (p < 0.05) in single women on Contraceptive when age [table 1] (15 – 20, 21 – 25 and 26 – 30yrs) and duration [table 2] ( < 1yr, 1 – 3yrs and > 4yrs) of intake was considered.

Conclusion(s): long term use of contraceptives raises the risk for blood clots or incessantly bleeding as it causes changes in the PT, FIB, APTT and TT levels of Single women in Calabar. Contraceptive should only be used by recommendations of health care providers. Hospitals, family planning clinics and fertility clinics should educate the general population on when to use contraceptives to avoid misuse. Policies should be made that regulate who sells contraceptive devices to avoid nonprescription of it in our society.