PB0687 - Comorbidities in an Aging Bleeding Disorder Population: A Retrospective Comparison Study.

Monday, June 26, 2023

18:30 – 19:30 ET

Room: Exhibition

Co-Author(s)

RD

Richard M. Daly

Final year Medical Student
University of Limerick.
Kells, Meath, Ireland

Co-Author(s)

MG

Mairead Goggin

Data Manager
Cork University Hospital
Cork, Cork, Ireland
BB

Brid Booth-Fleming

Haemophilia specialist nurse
Cork University Hospital
cork, Cork, Ireland
NC

Norma Collins

Haemophilia Specialist Nurse
Cork University Hospital
cork, Cork, Ireland
BF

Brid Firtear

Haemophilia Specialist Nurse
Cork University Hospital
Cork, Cork, Ireland
AR

Annmarie Ryan-Hall

Haemophilia Specialist nurse
Cork University Hospital
Cork, Cork, Ireland
CD

Cleona Duggan

Consultant Haematologist
Cork University Hospital
Cork, Cork, Ireland

Presenting Author(s)

MC

Maeve P. Crowley

Consultant Haematologist
Department of Haematology, Cork University Hospital, Wilton, T12 DC4A Cork, Ireland
Cork, Cork, Ireland

Background: The global population is growing; those over 65 years are the leading demographic. People with bleeding disorders (PWBD) are living longer than ever and experiencing diseases of ageing with specific management challenges. Little has been published on those with bleeding disorders other than haemophilia with a resultant underrepresentation of aging women.

Aims: Establish a comorbidity list of PWBD ≥50 years registered at a Comprehensive Coagulation Centre (CCC). Compare prevalence of chronic diseases in this cohort of PWBD’s to a national cohort study.

Methods: A list was generated from the National Haemophilia Database of patients registered at Cork University Hospital with a bleeding disorder and their medical records were reviewed. Inclusion criteria: Living patients ≥50 years diagnosed with a bleeding disorder (encompassing haemophilia, von Willebrand disease, factor deficiencies, platelet function abnormalities and unclassified bleeding disorders) and under active follow-up. Prevalence of co-morbidities was compared to a previously published Irish cohort study (TILDA).

Results: 103 patients were included in the study [median age 63.5 (range =50-90). 68% were women. Diabetes and cirrhosis were found to be at higher incidence in this cohort of patients; chronic obstructive pulmonary disease was not commonly seen. Anaemia burden was decreased in older PWBD’s (See figure and table).

Conclusion(s): The incidence of major comorbidities in PWBD ≥50 years appears comparable to an age matched cohort. Higher levels of diabetes and cancer and lower levels of hypertension were noted. Patients with severe factor VIII deficiency had no documented history of ischemic heart disease. This study looks at PWBDs of all severities and types and includes a large cohort of women. Anaemia burden was not a common issue in this cohort, suggesting that for many, once menstruation &/or childbearing ceases, many bleeding issues resolve. The clinical relevance of this work may influence the management of PWBD’s, to encourage diabetes and cardiovascular screening.