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    Joseph S. Palumbo, MD (he/him/his)

    Professor of Pediatrics
    University of Cincinnati and the Cincinnati Children's Hospital Medical Center
    Cincinnati, Ohio, United States

    I am a physician scientist with a clinical focus devoted to the care of children, adolescents and young adults with disorders or the hemostatic system, particularly those with thrombophilia and platelet dysfunction. A particular clinical interest is in the management of thrombophilia associated with complex pediatric heart disease, including the management of thrombotic complications associated with ventricular assist devices (VADS), Extracorporeal Membrane Oxygenation (ECMO), and patients with single ventricle physiology. Our basic science research program is focused on defining the mechanistic interplay of the hemostatic and immune systems in disease processes, including malignancy, colitis, and mechanical circulation. Our work has highlighted the fundamental importance of thrombin, the regulation of thrombin functions, and the platelet/fibrinogen axis in the metastatic process. We have also made significant contributions to understanding the role of hemostatic system components in tumorigenesis and tumor growth. Our work in this area has revealed a previously unrecognized role for thrombin-mediated procoagulant functions in tumorigenesis in the context of inflammatory colitis. We have an ongoing collaboration with Cardiothoracic Surgery to the define the mechanisms coupling contact pathway factors (factor XI, factor XII, prekallikrein) to thromboinflammatory complications in mechanical circulation (i.e., cardiopulmonary bypass and extracorporeal membrane oxygenation).

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