James V. Michael, PhD

Research Assistant professor
Thomas Jefferson University
Philadelphia, Pennsylvania, United States

I have a broad interest and background in the functional role of platelets as sentinel cells that balance hemostasis and thrombosis. My early work focused on exploring the production and function of noncoding RNAs in platelets and platelet-derived extracellular vesicles. More recent efforts have focused on the role platelets have as mediators between innate and adaptive immune responses. Our group has begun screening multiple classes of small molecules including inhibition of 12-LOX, testing ex vivo and in vivo efficacy as therapeutic agents in a mouse model of heparin-induced thrombocytopenia (HIT).

Presentation(s):

• OC 14.3 - A novel strategy to combat the procoagulant phenotype in immune thrombotic thrombocytopenia using 12-LOX inhibition

  Sunday, June 25, 2023
  11:15 – 11:30 ET

• PB0881 - Thrombin generation after initial cessation of bleeding is required for hemostatic plug stability via PAR-mediated platelet activation.

  Monday, June 26, 2023
  18:30 – 19:30 ET

• OC 61.5 - Plasma growth factors drive constitutive translation in circulating platelets to maintain protein homeostasis and regulate platelet GPCR reactivity and the hemostatic and thrombotic balance.

  Tuesday, June 27, 2023
  15:45 – 16:00 ET