Research Scientist II
Seattle Children's Research Institute
Seattle, Washington, United States
Chun-Yu Chen, Ph.D., is a research scientist in the Center for Immunity and Immunotherapies at Seattle Childrens Research Institute.
With more than 10 years of experience in human disease mouse models, including generating and analyzing transgenic and knockout mice using molecular biology, my research has been aimed at gene therapies for hemophilia A. I focus on using a non-viral system: lipid nanoparticles that can carry therapeutic mRNA or DNA to treat hemophilia A mice. I am designing new lipid nanoparticles that can carry CRISPR/Cas9 mRNA and sgRNA to correct the mutant FVIII gene in NSG hemophilia A mice. This strategy can help hemophilia A mice to regain endogenous FVIII protein expression and rescue bleeding phenotype.
Sunday, June 25, 2023
18:30 – 19:30 ET
Monday, June 26, 2023
11:15 – 11:30 ET