Graduate Student
University of North Texas
Denton, Texas, United States
Sanchi Manoj Dhinoja is a Ph.D. graduate student in Biochemistry and Molecular Biology Division in the Department of Biological Sciences at the University of North Texas, USA. Her choice of pursuing a Ph.D. was influenced by her experience as a licensed Genetic Counsellor and her deep empathy for patients suffering from genetic disorders. Under the guidance of Dr. Pudur Jagadeeswaran, a pioneer in the Genetics of Zebrafish Hemostasis, Sanchi is pursuing her doctoral degree on the topic of "Studies of Zebrafish Coagulation Factors". Her research has focused on exploring the similarities between zebrafish and human coagulation systems to investigate if mutations in clotting factor genes of zebrafish would mimic the conditions seen in patients with clotting factor deficiencies. Sanchi's work has included characterizing mutants for different coagulation factors, such as Gp1ba, FV, FVIII, and FII generated via ENU mutagenesis. She has successfully phenocopied symptoms in zebrafish mutants as seen in human patients suffering from similar mutations. Sanchi has also utilized CRISPR Cas9 technology and generated FIX-A and FIX-Like mutant zebrafish and is currently characterizing using functional assays to confirm the true human orthologue for Hemophilia B. Her research has the potential to contribute significantly to the development of new treatments for genetic disorders and improve the lives of patients around the world.
PB0155 - Characterization of zebrafish f8 mutant and modeling Hemophilia A
Sunday, June 25, 2023
18:30 – 19:30 ET