OC 41 - Contact Pathway: Structure and Function I

Moderator(s)

• 

  Joost Meijers, PhD (he/him/his)

  Professor
  Department of Experimental Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands
  Amsterdam, Noord-Holland, Netherlands
• 

  Bassem Mohammed, BPharm, PhD (he/him/his)

  Staff Scientist
  Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
  St. Louis, Missouri, United States

Presentations:

• 14:45 – 15:00 ET

  Structural Identification of the Factor XII - uPAR Binding Interface For Selective Drug Development.
  

  Presenting Author: Dillon J. Bohinc (he/him/his) – Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH, USA.

  Co-Author: Kara L. Bane – Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH, USA.

  Co-Author: Maria de la Fuente – Department of Pharmacology, CWRU School of Medicine, Cleveland, OH, USA.

  Co-Author: Shruti Raghunathan – Department of Biomedical Engineering, Case Western Reserve University

  Co-Author: Marvin T. Nieman – Case Western Reserve University

  Co-Author: Steven de Maat, PhD – Department of CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

  Co-Author: Helen Philippou, PhD – University of Leeds.

  Co-Author: Jonas Emsley, Phd – Nottingham Biodiscovery Institute, School of Pharmacy

  Co-Author: Coen Maas, PhD – CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  Co-Author: Thomas Renné – Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

  Co-Author: Anirban Sen Gupta, PhD (he/him/his) – Case Western Reserve University

  Co-Author: Evi X. Stavrou, MD – Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH, USA.
• 15:00 – 15:15 ET

  Coagulation factor XII-independent contribution of kallikrein to contact pathway-mediated thrombin generation in mouse whole blood
  

  Co-Author: Jun Wan, PhD (he/him/his) – Cyrus Tang Hematology Center, Soochow University

  Co-Author: Rohan Kathuri – University of North Carolina at Chapel Hill

  Co-Author: Sophia Dhrolia – University of North Carolina at Chapel Hill

  Co-Author: Mark Roest, PhD (he/him/his) – Department of Platelet pathophysiology, Synapse Research Institute, Maastricht, the Netherlands

  Co-Author: Alisa S. Wolberg, PhD – Univerisity of North Carolina at Chapel Hill

  Co-Author: Rafal Pawlinski, PhD – Division of Hematology and Blood Research Center, University of North Carolina at Chapel Hill

  Co-Author: Pavan K. Bendapudi – Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

  Co-Author: Nigel Mackman, PhD – Univerisity of North Carolina at Chapel Hill

  Presenting Author: Steven P. Grover, PhD – Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill
• 15:15 – 15:30 ET

  Intramolecular interactions that stabilize factor XII in a closed form
  

  Co-Author: ALEKSANDR SHAMANAEV, PhD – Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center

  Co-Author: Maxim Litvak, MD PhD – Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center

  Co-Author: Jonas Emsley, Phd – Nottingham Biodiscovery Institute, School of Pharmacy

  Presenting Author: David Gailani, MD – Vanderbilt University Medical Center
• 15:45 – 16:00 ET

  Two positively charged patches in the EGF-1 domain of Factor XII synergistically contribute to surface binding and activation
  

  Presenting Author: Rowan Frunt, MSc – Department of CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  Co-Author: Hinde El Otmani, MSc – Department of CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  Co-Author: Simone Smits – Department of CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  Co-Author: Chantal Clark – Van Creveldkliniek - Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  Co-Author: Coen Maas, PhD – CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands