OC 44 - Hemophilia Basic Science - Inhibitors

Moderator(s)

• 

  Margaret Ragni, MD, MPH (she/her/hers)

  Professor of Medicine and Clinical and Translational Science
  Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  Pittsburgh, Pennsylvania, United States
• 

  Davide Matino, MD (he/him/his)

  Assistant Professor
  Medicine
  Department of Medicine, Division of Hematology, McMaster University, Hamilton, ON
  Hamilton, Ontario, Canada

Presentations:

• 14:45 – 15:00 ET

  Structural studies of blood coagulation factor VIII bound to patient-derived inhibitory antibodies
  

  Co-Author: Kenneth C. Childers – Western Washington University

  Co-Author: Nathan Avery – Western Washington University

  Co-Author: Pete Lollar – Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine

  Co-Author: Chris Doering – Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine

  Co-Author: Carmen Coxon – Department of Biotherapeutics, National Institute for Biological Standards and Control

  Presenting Author: Paul C. Spiegel, Jr., PhD (he/him/his) – Western Washington University
• 15:00 – 15:15 ET

  Developing humanized mouse models as a testing platform for immune tolerance induction therapy for antibody-positive hemophilia A patients
  

  Presenting Author: Li-Fu Chen – Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University

  Co-Author: Sheng-Chieh Chou, MD. (he/him/his) – Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital

  Co-Author: Yi-Hsuan Wu – Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University

  Co-Author: Yen-Ting Chang – Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University

  Co-Author: Chien-Hong Liu – Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University

  Co-Author: Chin-Yu Cheng – Department of Laboratory Medicine, National Taiwan University Hospital

  Co-Author: Bin-Bin Lin – Department of Laboratory Medicine, National Taiwan University Hospital

  Co-Author: Cheng-An Hsu – Department of Laboratory Medicine, National Taiwan University Hospital

  Co-Author: I-Shing Yu – Laboratory Animal Center; Collage of Medicine, National Taiwan University

  Co-Author: Shu-Wha Lin – Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University; Department of Laboratory Medicine, National Taiwan University Hospital
• 15:15 – 15:30 ET

  Exploring red blood cells as a novel tolerogenic approach for factor VIII inhibitors employing immuno-dominant FVIII derived peptides presented on MHC class II
  

  Presenting Author: Mariarosaria Miranda, MA – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands

  Co-Author: Eelke Brandsma – Department of Hematopoiesise, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Paul Kaijen – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Floris Van Alphen – Department of Molecular Hematology, Sanquin Research, 1066 CX Amsterdam, the Netherlands

  Co-Author: Robin Van Bruggen – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Karin Fijnvandraat – Amsterdam UMC, University of Amsterdam, Emma Children’s Hospital, Pediatric Hematology Amsterdam, Netherlands

  Co-Author: Sebastien Lacroix-Desmazes, PhD – Centre De Recherche Des Cordeliers, Paris, France

  Co-Author: Jan Voorberg – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory
• 15:30 – 15:45 ET

  Association of chemokine CXCL13 and follicular helper T cells in hemophilia A patient and murine model with inhibitors
  

  Presenting Author: Yingyu Chen, PhD – Department of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital

  Co-Author: Liping Luo – Department of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital

  Co-Author: Qiaoyun Zheng – Department of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital

  Co-Author: Zhenyu Chen – Department of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital

  Co-Author: Qizhen Shi, MD, PhD – Medical College of Wisconsin, Versiti Blood Research Institute, Children's Research Institute
• 15:45 – 16:00 ET

  A gut metabolite-based dietary therapy influences FVIII inhibitor production with novel relationships between the gut microbiota, blood metabolome, and immune cell frequencies
  

  Presenting Author: Matthew Cormier, PhD (he/him/his) – Queen's University

  Co-Author: Erin Burnett – Queen's University, Pathology and Molecular Medicine

  Co-Author: Kate Nesbitt – Queen's University

  Co-Author: Aomei M. Mo – Queen's University

  Co-Author: Eliana Marino – Monash University

  Co-Author: Christine Hough – Queen's University

  Co-Author: David Lillicrap, MD – Department of Pathology and Molecular Medicine, Queen's University