OC 39 - Platelet Production from Megakaryocytes

Moderator(s)

• 

  Kellie Machlus, PhD

  Assistant Professor
  Surgery
  Boston Children's Hospital
  Boston, Massachusetts, United States
• 

  Eric Boilard, PhD (he/him/his)

  Professor
  Centre de Recherche du CHU de Québec- Université Laval, Quebec, Canada

Presentations:

• 10:45 – 11:00 ET

  Anti-integrin immune thrombocytopenia autoantibodies impair megakaryocyte migration, polarization and proplatelet formation.
  

  Presenting Author: Francesca Tondi, MS – University of Perugia, Departement of Medicine and Surgery, Section of Internal and Cardiovascular Medicine

  Co-Author: Elisa Giglio – Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia

  Co-Author: Eleonora Petito, Post Doc – Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia

  Co-Author: Loredana Bury, PhD – Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia

  Co-Author: Paolo Gresele, MD, PhD – Dept. of Medicine and Surgery, University of Perugia

  Co-Author: Anna Maria Mezzasoma – Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia
• 11:00 – 11:15 ET

  Megakaryocytes derived from human CD34+ cells express and release Brain-Derived Neurotrophic Factor
  

  Presenting Author: Imane Boukhatem, MSc – Faculty of pharmacy, University of Montreal

  Co-Author: Mélanie Welman, PhD (she/her/hers) – Montreal Heart Institute

  Co-Author: Sonia POIRAULT-CHASSAC – Neurocentre Magendie, INSERM U1215, Bordeaux Neurocampus, Bordeaux, France

  Co-Author: Christilla BACHELOT-LOZA – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Pascale Gaussem – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Bruce Allen – Faculty of medicine, University of Montreal

  Co-Author: Guillaume Lettre – Faculty of medicine, University of Montreal

  Co-Author: Marie Lordkipanidzé, B.Pharm, PhD (she/her/hers) – Faculty of pharmacy, University of Montreal
• 11:15 – 11:30 ET

  Platelet Biogenesis from Mouse Megakaryocytes at Variable Shear Stress Levels by Using Microfluidic Systems
  

  Co-Author: Semra Z. Birol, PhD – School of Physiology, Pharmacology and Neuroscience/University of Bristol

  Presenting Author: Jordan Vautrinot, Bsc – University of bristol

  Co-Author: Xiaojuan Zhao – School of Physiology, Pharmacology and Neuroscience/University of Bristol

  Co-Author: Muhammed E. Polat – Faculty of Mechanical Engineering/Istanbul Technical University

  Co-Author: Sertac Cadirci – Faculty of Mechanical Engineering/Istanbul Technical University

  Co-Author: Levent Trabzon – Faculty of Mechanical Engineering/Istanbul Technical University

  Co-Author: Alastair W. Poole – School of Physiology, Pharmacology and Neuroscience/University of Bristol
• 11:30 – 11:45 ET

  Use of an in vitro platelet production approach to assess the effects of chronic cigarette and e-cigarette exposure on platelet generation and function.
  

  Presenting Author: Jordan Vautrinot, Bsc – University of bristol

  Co-Author: Xiaojuan Zhao – School of Physiology, Pharmacology and Neuroscience/University of Bristol

  Co-Author: Christopher M. Williams – University of bristol

  Co-Author: Alastair W. Poole – School of Physiology, Pharmacology and Neuroscience/University of Bristol
• 11:45 – 12:00 ET

  Lung megakaryocytes are tissue resident, arise independent of HSCs, and contribute to recovery in low platelet states.
  

  Presenting Author: Alison C. Livada, MS (she/her/hers) – University of Rochester

  Co-Author: Sara Ture – University of Rochester

  Co-Author: Kathleen McGrath – University of Rochester

  Co-Author: James Palis – University of Rochester

  Co-Author: Craig N. Morrell, DVM, PhD (he/him/his) – University of Rochester