PB0103 - Disturbance of the hemostatic balance in outpatients with Covid-19

Background: Infection with SARS-- CoV-2 virus, results in systemic inflammatory response and imbalance between homeostatic mechanisms of procoagulant and anticoagulant.Coagulation test with other laboratory parameters, can actually give us an indication of the severity of disease.

Aims: The purpose of this study: evaluate the hemostasis parameters in a cohort of ambulatory patients, and the association between the altered parameters of hemostasis with other laboratory tests.

Methods: We studied 35 ambulatory patients randomly selected , with previous diagnosis of infection; Median age 52 years; 8 females – 27 males.Blood coagulation parameters included the measured of Prothrombin Time (PT), APTT, Fibrinogen (FIB), von Willebrand Factor (VWF), Factor VIII (VIII), Instrumentation Laboratory (IL) performed in an ACL TOP 300 (IL) and D-Dimer (DD) immunoenzymatic; Biomerieux Vidas.As other Laboratory test we performed Ferritin (Fer), Covas Roche.

Results: All patients presented positive RT- PCR between 5 and 10 days prior to sample collection,and all of them were outpatients. Routine parameters were almost not affected.In contrast FIB was elevated in 54%, VWF 97%, VIII 51%, DD 69% and Fer 77%.

Conclusion(s): As it was shown in hospitalized patients, coagulation abnormalities and elevated values of endothelial activation markers are typical findings;even in those patients who were never hospitalized. In some cases,levels are three or four times higher than the reference range.