PB1545 - Antiphospholipid antibodies profile in women with periodontal disease

Tuesday, June 27, 2023

18:30 – 19:30 ET

Room: Exhibition

Presenting Author(s)

Patricia Casais, MD, PhD, MSc (she/her/hers)

Physician- Researcher
University of Buenos Aires, Argentina
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina

Co-Author(s)

SP

Silvina Pons

Biochemist
Facultad Farmacia y Bioquímica. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
MH

Ma. Lourdes Herrera

Biochemist
Facultad Farmacia y Bioquímica. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
SB

Silvina Bonaccorso

Hematologist
Hospital de Clinicas, Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
VM

Valeria Monserrat

Biochemist
Facultad Farmacia y Bioquímica. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
LD

Luciana D´Eramo

Dentist
Facultad de Odontologia. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
MN

Mauricio Nieto

Dentist
Facultad de Odontologia. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
AS

Aldo Squassi

Dentist
Facultad de Odontologia. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
AS

Alejandra Scazziota

Biochemist
Facultad Farmacia y Bioquímica. Universidad de Buenos Aires
Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina

Background: Periodontitis (PD) is a multifactorial disease. Anticardiolipin antibodies (aCL) are found in 15-20% of PD patients. Obstetrical complications in PD are similar to those of the antiphospholipid syndrome. The mechanisms of pregnancy complications in PD have not been elucidated. The prevalence of aCL, lupus anticoagulant (LA) and antiβ2 glycoprotein I (aβ2GPI) in PD and its association with pregnancy complications is unknown.

Aims: To determine the frequency of aCL, LA, aβ2GPI in young women with PD.

Methods: We designed a case-control study to evaluate LA, ACA and aβ2GPI in young women with PD and its association with adverse pregnancy outcomes. We report the preliminary frequency of antiphospholipid antibodies (aPL) in this population. Cases: women of reproductive age with PD and a pregnancy within the last five years. Controls: same characteristics except no PD. Exclusion criteria: corticosteroids or direct oral anticoagulants use. Clinical and obstetric history was recorded. Lab tests: LA detection (according to ISTH guidelines), aCL and aβ2GPI IgG/ IgM antibodies (ELISA ORGENTEX).
The study was approved by the Ethics Committee, University of Buenos Aires.

Funding: grants by the Ministry of Health and the Argentine Cooperative Group on Thrombosis and Hemostasis. All participants signed the written consent. Descriptive statistics were performed.

Results: We report the frequency of aPL in 49 patients (28 cases and 21 controls; 34.8±2.2 and 31±1.8 years old, respectively). None of the controls had a positive aPL test. In 8/28 cases (28%), we observed LA, or moderate/high titers of aCL and/or aβ2GPI. However, only two cases (7.1%) had either LA (a patient with dermatomyositis) or high titers of aCL IgG (96 GPL) and aβ2GPI IgG (71 GPL).

Conclusion(s): We observed a higher frequency of aPL in women with PD compared to those with periodontal health. The study continues to include more patients in order to confirm these observations.