PB1519 - Analysis of aggregation patterns changes in pregnant women with severe preeclampsia

Background: Platelet aggregation is the main functional element of vascular-platelet hemostasis. Changes in this condition underlie the pathogenesis of preeclampsia.

Aims: The aim of the study was to study changes in platelet hemostasis in women with preeclampsia.

Methods: We conducted a study of 150 pregnant women in the third trimester, of which 40 pregnant women with a physiological course of the gestational period (control group) and 110 pregnant women with preeclampsia (main group). The age of the examined women ranged from 19 to 42 years. We investigated the platelet, procoagulant link of blood coagulation inhibitors and the fibrinolytic link of the hemostasis system.

Results: The mean values of the aggregation intensity indicators were significantly higher in main group than in conditionally healthy pregnant women. The increase in the intensity of aggregation in pregnant women with preeclampsia with ADP stimulation of 1 10-3 m was 16.1 and 7.9%, respectively; ADP 1 10-5 m - 15.1 and 10.6%; ADP 1 10-7 m - 62.3 and 62.2%; adrenaline - 27.4 and 30.3% (P < 0.01).
The intensity of secondary platelet aggregation during stimulation with ADP 1 10-5m and adrenaline was also significantly higher than in conditionally healthy women (P < 0.001). At the same time, the slope of the aggregogram curve at the stage of secondary aggregation exceeded that in healthy pregnant women (by 5.8%, respectively) (P>0.05). When analyzing the aggregation parameters characterizing the dynamics of the secretory activity of platelets, an accelerated onset of the reaction of the release of endogenous stimulators of aggregation and the synthesis of cyclic endoperoxides of prostaglandins and thromboxane A2 was noted.

Conclusion(s): Thus, pregnant women with preeclampsia have signs of a subacute form of disseminated intravascular coagulation syndrome and signs of thrombocytopathy and consumption coagulopathy in combination with a decrease in the anticoagulant and fibrinolytic potential of the blood.