Professor Soonchunhang University Gumi Hospital Gumi, Kyongsang-bukto, Republic of Korea
Background: Venous thromboembolism (VTE) is very fatal if it is not adequately treated timely. However, the proper time to start anticoagulants in patients who had VTE developed after intracerebral hemorrhage (ICH) remains uncertain due to concerns about rebleeding of ICH.
Aims: This study aims to evaluate the bleeding risk of treatment of VTE in patients with recent ICH.
Methods: We reviewed retrospectively the medical charts to detect the patients with VTE after ICH between 2013 and 2022, in a single institute. We categorized the patients into the early diagnosis group ( < 14 days) and the late diagnosis group (≥14 days) according to the period between ICH and VTE diagnosis. We started to use 30mg of Enoxaparin once a day within 1.9 days (range, 0–7) after the VTE diagnosis
Results: Of the 7 patients, 5 were female and mean age was 74.5 (range: 54–88). Mean duration between ICH and anticoagulation was 6.7 days (5–10) in early group and 29 days (range, 20–48) in late group. Among 3 patients in early group there was no intracranial rebleeding, whereas among 4 patients in the late group one patients had intracranial rebleeding and other patient had major bleeding which required 2 units of transfusion.
Conclusion(s): Initiation of anticoagulation within 14 days after ICH does not appear to increase the risk of rebleeding of ICH.