PB1410 - The association between microvascular health and coagulation parameters: the Netherlands Epidemiology of Obesity Study

Tuesday, June 27, 2023

18:30 – 19:30 ET

Room: Exhibition

Co-Author(s)

LY

Lushun Yuan

PhD student
Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Nephrology, Leiden University Medical Center, Leiden, the Netherlands.
Leiden, Zuid-Holland, Netherlands

Presenting Author(s)

Jihee Han, MS

PhD student
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Leiden, Zuid-Holland, Netherlands

Co-Author(s)

AI

Anouk I.M. van der Velden

PhD student
Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Nephrology, Leiden University Medical Center, Leiden, the Netherlands.
Leiden, Zuid-Holland, Netherlands
HV

Hans Vink

Professor
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands.
Leiden, Zuid-Holland, Netherlands
Rd

Renée de Mutsert

Associate professor
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Leiden, Zuid-Holland, Netherlands
FR

Frits R. R. Rosendaal

Professor
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Leiden, Zuid-Holland, Netherlands
Astrid van Hylckama Vlieg, PhD

Associate Professor
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Leiden, Zuid-Holland, Netherlands
Ruifang Li-Gao, PhD (she/her/hers)

postdoc
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Leiden, Zuid-Holland, Netherlands
TJ

Ton J Rabelink

Professor
Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Nephrology, Leiden University Medical Center, Leiden, the Netherlands.
Leiden, Zuid-Holland, Netherlands
BM

Bernard M. van den Berg

Assistant professor
Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Nephrology, Leiden University Medical Center, Leiden, the Netherlands.
Leiden, Zuid-Holland, Netherlands

Background: Dysregulation of the coagulation system is involved in coronary heart disease (CHD) pathogenesis and can be induced by endothelial glycocalyx (EG) perturbation. However, little is known about the link between EG function and coagulation parameters, and whether this relation differs between men and women.

Aims: We sought to examine the association between EG function and coagulation parameters in a middle-aged Dutch population and to assess potential sex differences in these associations.

Methods: Using baseline measurements of 771 participants from the Netherlands Epidemiology of Obesity study, associations between glycocalyx-related perfused boundary region (PBR) derived from sidestream dark-field imaging and coagulation parameters (factor (F) VIII, FIX, FXI, thrombin generation parameters, and fibrinogen) were investigated using linear regression analyses, adjusting for age, sex, BMI, smoking, menopausal, hormone therapy, C-reactive protein, glycoprotein acetyls, and leptin, followed by sex-stratified analyses.

Results: The median age was 56 (51-61) years and 53% were women. In the total population, only PBR feed vessel, indicating poorer glycocalyx status, was associated with fibrinogen levels. There was a sex difference in the associations between PBR and coagulation parameters. No associations were observed in men, while in women one SD PBR (both total and feed vessel) was associated with elevated FIX activity (1.8%, 95% CI: 0.3-3.3, and 2.0%, 95% CI: 0.5-3.4) and plasma fibrinogen levels (5.1 mg/dL, 95% CI: 0.4-9.9, and 5.8 mg/dL, 95% CI: 1.1-10.6) after adjusting for confounders. Furthermore, one SD PBR capillary was associated with elevated FVIII activity (3.5%, 95% CI: 0.4-6.5) and plasma fibrinogen levels (5.3 mg/dL, 95% CI: 0.6-10.0) after adjusting for confounders. No associations with other coagulation parameters were observed.

Conclusion(s): We showed a sex-specific association between microcirculatory health and procoagulant factors, which suggests microvascular health may be considered in the early development of CHD in women.