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    Poster Networking

    Hemophilia and Rare Bleeding Disorders

    Poster Networking Session

    PB1247 - Iron deficiency in inherited bleeding disorders in a hemophilia center

    Tuesday, June 27, 2023
    18:30 – 19:30 ET
    Room: Exhibition
    Background: Iron deficiency anemia is an important cause of decreased quality of life. Inherited bleeding disorders are often responsible for iron deficiency, due to the associated bleeding risk.

    Aims: To evaluate the prevalence of iron deficiency in inherited bleeding disorders followed at our center.

    Methods: We did a retrospective analysis of all the patients that had at least one appointment in our inherited bleeding disorders reference center in the year 2022. We underwent a case by case investigation of blood workups available in our hospital to diagnose iron deficiency and reviewed the patient's registries for iron supplementation. We only considered patients that already had a diagnosis and excluded all that are still being studied.

    Results: Of the 548 patients that had an appointment in our center last year, 367 had a clinical and laboratory diagnosis, while the others were found to have no bleeding disorders or needed to undergo further investigation. The mean age was 46 (range 5 months to 88 year-old). The prevalence according to each inherited bleeding disorder is expressed in table 1. We defined mixed disorders as patients with more than one type of bleeding disorders.

    Conclusion(s): We verified that in patients with bleeding disorders related to primary haemostasis there was a greater prevalence in iron deficiency. More than 1/3 of all patients with von willebrand disease (and 62,5% of patients with type 3) and 75% of patients with Glanzmann Thrombasthenia needed iron supplementation. Besides the increase in muco-cutaneous bleeding, platelets disorders can be associated with more iron deficiency due to the nature of their treatment (on demand) versus ongoing therapeutic prophylaxis in patients with severe haemophilia. As such, iron levels need to be regularly checked in order to improve patient’s lives and avoid transfusion requirements.