Skip to main content
ISTH 2023 Main banner
Back

    Poster Networking

    Hemophilia and Rare Bleeding Disorders

    Poster Networking Session

    PB0671 - Poor correlation between biomarkers and MRI-detected joint damage in a cross-sectional study of persons with non-severe hemophilia A

    Monday, June 26, 2023
    18:30 – 19:30 ET
    Room: Exhibition

      Co-Author(s)

    • FK

      Fabienne R. Kloosterman, MD

      PhD candidate
      Amsterdam UMC, University of Amsterdam, Emma Children’s Hospital, Pediatric Hematology, Meibergdreef 9, Amsterdam, Netherlands
      Utrecht, Utrecht, Netherlands

      • Co-Author(s)

    • AZ

      Anne-Fleur Zwagemaker

      PhD candidate
      Amsterdam UMC, University of Amsterdam, Emma Children’s Hospital, Pediatric Hematology, Meibergdreef 9, Amsterdam, Netherlands
      Amsterdam, Noord-Holland, Netherlands

    • AB

      Anne C. Bay-Jensen

      Director of ImmunoScience and Chief Technology Officer
      Immunoscience, Nordic Bioscience , Biomarkers and Research, Herlev, Denmark
      Herlev, Sjelland, Denmark

    • MC

      Marjon H. Cnossen

      Associate professor, pediatric hematologist, MD, PhD
      Department of Pediatric Hematology, Erasmus MC – Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
      Rotterdam, Zuid-Holland, Netherlands

    • MK

      Marieke J.H.A. Kruip

      Associate professor, hematologist, MD, PhD
      Department of Hematology, Erasmus MC, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
      Rotterdam, Zuid-Holland, Netherlands

    • Frank W.G. Leebeek, MD, PhD

      Professor and Head of Department of Hematology
      Erasmus MC, University Medical Center Rotterdam, The Netherlands
      Rotterdam, Zuid-Holland, Netherlands

    • RH

      Robert Hemke

      PhD, MD
      Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands
      Amsterdam, Noord-Holland, Netherlands

    • MM

      Mario Maas

      Professor of Radiology
      Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands
      Amsterdam, Noord-Holland, Netherlands

    • KF

      Karin Fijnvandraat

      Professor
      Amsterdam UMC, University of Amsterdam, Emma Children’s Hospital, Pediatric Hematology Amsterdam, Netherlands
      Amsterdam, Noord-Holland, Netherlands

    • Samantha Gouw, MD, PhD (she/her/hers)

      Pediatric Hematologist
      The University of Amsterdam
      Amsterdam, Noord-Holland, Netherlands

      • Presenting Author(s)

    • Michiel Coppens, MD, PhD (he/him/his)

      Medical Specialist
      Amsterdam University Medical Centers, Amsterdam, The Netherlands
      Amsterdam, Noord-Holland, Netherlands

    Background: Persons with non-severe hemophilia A (NSHA) experience less frequent joint bleeding than persons with severe hemophilia A but may still develop joint damage. Biomarkers of cartilage and synovial remodelling can reflect ongoing pathological processes that may precede or coincide with damage on joint imaging. If so, biomarkers may be an important diagnostic tool for joint damage in NSHA.

    Aims: To assess the correlation between biomarkers and MRI-detected joint damage in persons with NSHA.

    Methods: In a cross-sectional study, males with NSHA (FVIII 2-35 IU/dL) were included. Participants underwent MR imaging of elbows, knees and ankles and blood and urine sampling for biomarker analysis on a single visit. The following biomarkers were analyzed: urinary CTX-II, sCOMP, CS-846, VCAM-1, osteopontin, C2M, PRO-C2, C4M and PRO-C4. Spearman’s rank correlations were calculated between these biomarkers and the total IPSG score, soft-tissue sub-score and osteochondral sub-score. Medical ethics approval and written consent was obtained (ClinicalTrials.gov Identifier: NCT03623295).

    Results: In total, 48 persons with NSHA were included. Median age was 43 years (range 24-55) and median FVIII was 10 IU/dl (IQR 4-16). The median IPSG score was 4 (IQR 2-9). Median IPSG soft-tissue subscores were 3 (IQR 2-4) and osteochondral subscores were 0 (IQR 0-4). No strong correlations were found between the studied biomarkers, total IPSG score, subsequent soft-tissue and osteochondral sub-scores. Table 1 presents the correlation coefficients between the biomarkers and IPSG (sub-)scores.

    Conclusion(s): In this study, selected biomarkers indicative of different aspects of hemophilic arthropathy showed no consistent correlation with IPSG scores. This suggests that systemically measured biomarkers are currently not suitable to identify milder joint damage in NSHA as observed on MRI.