Michael Holinstat, PhD

Associate Professor of Pharmacology
University of Michigan
Ann Arbor, Michigan, United States

Michael Holinstat, PhD, FAHA, Associate Professor of Pharmacology, University of Michigan Medical School, is a platelet pharmacologist studying how lipids and their oxylipins regulate platelet function. My lab focuses on eicosanoids and the enzymes that regulate their formation such as 12-lipoxygenase to understand how their mechanistically regulate platelet reactivity, clot formation, hemostasis, and thrombosis. We have identified a number of oxylipins that regulate platelet function, hemostasis, and thrombosis. Development of CS585 stemmed from the discovery of 12(S)-HETrE formation in the platelet.

Presentation(s):

• OC 14.3 - A novel strategy to combat the procoagulant phenotype in immune thrombotic thrombocytopenia using 12-LOX inhibition

  Sunday, June 25, 2023
  11:15 – 11:30 ET

• OC 61.3 - CS585 is a novel and highly selective IP receptor agonist for prevention of thrombosis

  Tuesday, June 27, 2023
  15:15 – 15:30 ET

• OC 62.5 - Next-generation, dendrimer-like polyphosphate inhibitor is a safe and effective antithrombotic agent

  Tuesday, June 27, 2023
  15:45 – 16:00 ET