Skip to main content
ISTH 2023 Main banner
Back
    Oral Communication

    Platelets and Megakaryocytes
    Oral Communication Session

    OC 61 - Manipulating Platelet Function

    Tuesday, June 27, 2023
    14:45 – 16:00 ET
    Room:710A

    Session Available Online As: On-Demand

    Presentations:

    • 14:45 – 15:00 ET
      Optimization and Delivery of Endogenous mRNA UTRs using LNPs to Control Exogenous Protein Expression in Platelets

      Presenting Author: Madelaine K. Robertson – University of British Columbia

      Co-Author: Jerry Leung (he/him/his) – The University of British Columbia

      Co-Author: Colton Strong (he/him/his) – The University of British Columbia

      Co-Author: Katherine Badior, PhD – Versiti Blood Research Institute

      Co-Author: Eric Jan – University of British Columbia

      Co-Author: Pieter Cullis – The University of British Columbia

      Co-Author: Christian Kastrup, PhD – Versiti Blood Research Institute

    • 15:00 – 15:15 ET
      MiR-146a-mimic therapy modulates platelet reactivity preventing mortality caused by pulmonary embolism model

      Presenting Author: Sonia Aguila, PhD (she/her/hers) – Centro Regional de Hemodonación, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: Juan carlos Garcia-Cañaveras – Biomarkers and Precision Medicine Unit, Instituto de Investigación Sanitaria Fundación Hospital La Fe, Valencia, Spain

      Co-Author: Ascension M M. De los Reyes-Garcia, MSc – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: Laura Zapata-Martinez – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: Nuria Garcia-Barbera – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: Pedro J Guijarro – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: María Luisa Lozano – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER, Murcia, Spain

      Co-Author: Bernard Payrastre – INSERM, UMR-S U1297 and University of Toulouse III, Institute of Cardiovascular and Metabolic Diseases (I2MC), CHU-Rangueil, laboratoire d'Hématologie, CHU de Toulouse, Toulouse, France

      Co-Author: José RIVERA Rivera, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: Marie Pierre Gratacap – INSERM, UMR-S U1297 and University of Toulouse III, Institute of Cardiovascular and Metabolic Diseases (I2MC), CHU-Rangueil, Toulouse, France

      Co-Author: Agustin Lahoz – Biomarkers and Precision Medicine Unit, Instituto de Investigación Sanitaria Fundación Hospital La Fe, Valencia, Spain

      Co-Author: Marcin kortylewski – Center for Gene Therapy and Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, California, US

      Co-Author: Rocio Gonzalez-Conejero – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, Murcia, Spain

      Co-Author: Constantino Martinez, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, Murcia, Spain

    • 15:15 – 15:30 ET
      CS585 is a novel and highly selective IP receptor agonist for prevention of thrombosis

      Co-Author: Sylviane Lambert – University of Michigan

      Co-Author: Livia Stanger – University of Michigan

      Co-Author: Adriana Yamaguchi – University of Michigan

      Co-Author: Pooja Yalavarthi – University of Michigan

      Co-Author: Andrew Rickenberg – University of Michigan

      Co-Author: Niklas Bergh – Institute of Medicine, University of Gothenburg

      Co-Author: Bjorn Dahlof – Institute of Medicine, University of Gothenburg

      Presenting Author: Michael Holinstat, PhD – University of Michigan

    • 15:30 – 15:45 ET
      Manipulating platelet secretion to affect hemostasis

      Presenting Author: Smita Joshi, PhD (she/her/hers) – Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA

      Co-Author: Alexis N. Smith (she/her/hers) – Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA

      Co-Author: Hammodah R. Alfar – Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA

      Co-Author: Kanakanagavalli Shravani Prakhya, PhD (she/her/hers) – Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA

      Co-Author: Irina Pokrovskaya – University of Arkansas for Medical Sciences

      Co-Author: Harry Chanzu – GenScript

      Co-Author: Brian Storrie – University of Arkansas for Medical Sciences

      Co-Author: Sidney W. Whiteheart – Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA

    • 15:45 – 16:00 ET
      Plasma growth factors drive constitutive translation in circulating platelets to maintain protein homeostasis and regulate platelet GPCR reactivity and the hemostatic and thrombotic balance.

      Presenting Author: Lawrence E. Goldfinger, PhD (he/him/his) – Thomas Jefferson University

      Co-Author: Jeremy Wurtzel – Thomas Jefferson University

      Co-Author: Sophia Lazar – Thomas Jefferson University

      Co-Author: Shayan Askari – Thomas Jefferson University

      Co-Author: Xuefei Zhao – Thomas Jefferson University

      Co-Author: Jenna R. Severa, BS – Thomas Jefferson University

      Co-Author: James V. Michael, PhD – Thomas Jefferson University

      Co-Author: Steven E McKenzie, MD, PhD – Thomas Jefferson University

      Co-Author: Timothy J. Stalker – Thomas Jefferson University

      Co-Author: Peisong Ma, PhD – Thomas Jefferson University