OC 58 - Platelet Signaling

Moderator(s)

• 

  Peisong Ma, PhD

  Assistant Professor
  Thomas Jefferson University
  Philadelphia, Pennsylvania, United States
• 

  Georges JOURDI, PharmD, PhD (he/him/his)

  Associate Professor in Hematology
  Université Paris Cité and APHP. Nord
  Paris, Ile-de-France, France

Presentations:

• 10:45 – 11:00 ET

  Circulating endoglin decreases platelet aggregation and thrombus formation through interaction with the αIIbβ3 integrin
  

  Presenting Author: Elisa Rossi, PhD (she/her/hers) – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Miguel Pericacho – Department of Physiology and Pharmacology, University of Salamanca, Spain

  Co-Author: Alexandre KAUSKOT – INSERM U1176, Hôpital Bicêtre

  Co-Author: Luis Gamella-Pozuelo – Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

  Co-Author: Etienne Reboul – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Iles Saidi – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Alexandre Leuci – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Cristina Egido-Turrion – Department of Physiology and Pharmacology, University of Salamanca, Spain

  Co-Author: DIVINA El Hamaoui – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Aurore Marchelli – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Francisco J. Fernández – Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC),Madrid, Spain

  Co-Author: Isabelle Margaill – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Cristina Vega – Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC),Madrid, Spain

  Co-Author: Pascale Gaussem – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Samuela Pasquali – Cibles Thérapeutiques et Conception de Médicaments CiTCoM -UMR8038 CNRS, Paris, France

  Co-Author: David Smadja, PhD (he/him/his) – Université Paris Cité

  Co-Author: Christilla Bachelot-Loza – Université Paris Cité, INSERM U1140, Innovative Therapies in Haemostasis, France

  Co-Author: Carmelo Bernabeu – Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
• 11:00 – 11:15 ET

  Conformational Change in Platelet αIIbβ3 Induce PKC-dependent Serine 284 Phosphorylation of Junctional Adhesion Molecule-A and Rap1 Activation
  

  Presenting Author: Meghna U. Naik, MS – Thomas Jefferson University

  Co-Author: Meghna U. Naik, MS – Thomas Jefferson University

  Co-Author: Ulhas P. Naik – Thomas Jefferson University
• 11:15 – 11:30 ET

  Affinity of anti-GPVI antibodies determines the degree of human and mouse GPVI depletion in vivo
  

  Presenting Author: Stefano Navarro, PhD (he/him/his) – University hospital Würzburg

  Co-Author: Sarah Beck, PhD – Institute of Experimental Biomedicine - Chair I, University Hospital and Rudolf Virchow Center for Integrative and Translational Bioimaging, Würzburg, Germany

  Co-Author: Marijke Kuijpers – Maastricht University

  Co-Author: Johan W. M. Heemskerk – Synapse research insitute

  Co-Author: David Stegner, PhD (he/him/his) – Institute of Experimental Biomedicine - Chair I, University Hospital and Rudolf Virchow Center for Integrative and Translational Bioimaging, Würzburg, Germany

  Co-Author: Bernhard Nieswandt – Institute of Experimental Biomedicine - Chair I, University Hospital Würzburg and Rudolf Virchow Center for Integrative and Translational Biomaging, University of Würzburg, Germany
• 11:30 – 11:45 ET

  CIB1 Binding to Cytoplasmic Tail of αIIb Is Required for αIIbβ3 Activation in Platelets
  

  Presenting Author: Deepa Gautam, PhD (she/her/hers) – Thomas Jefferson University

  Co-Author: Kalyan Golla – University of British Columbia

  Co-Author: Meghna U. Naik, MS – Thomas Jefferson University

  Co-Author: John C. Kostyak, PhD – THOMAS JEFFERSON UNIVERSITY

  Co-Author: Ulhas P. Naik – Thomas Jefferson University
• 11:45 – 12:00 ET

  Cooperation between platelet β1 and β3 integrins in the arrest of bleeding under inflammatory conditions in mice
  

  Presenting Author: Emily Janus-Bell, PhD (she/her/hers) – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Nicolas Receveur – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Luc Mercier – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Clarisse Mouriaux – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Béatrice Hechler, PhD – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Jochen Reiser – Department of Medicine, Rush University Medical Center, Kellogg Building, Suite 1003, Chicago, IL 60612, USA

  Co-Author: Benoît Ho-Tin-Noé, PhD – Université de Paris Descartes, INSERM, Hôpital Bichat, UMR-S1148, F-75000 Paris, France

  Co-Author: Pierre Mangin – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France