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    Oral Communication

    Platelet Disorders, VWD, and Thrombotic Microangiopathies
    Oral Communication Session

    OC 13 - von Willebrand Factor Biology

    Sunday, June 25, 2023
    10:45 – 12:00 ET
    Room:710B

    Session Available Online As: On-Demand

    Presentations:

    • 10:45 – 11:00 ET
      Scavenger Receptor Stabilin-2 is a Major Regulator of VWF Propeptide Clearance

      Presenting Author: Orla Rawley, PhD (she/her/hers) – Queen's University, Pathology and Molecular Medicine

      Co-Author: Christine Brown – Queen's University

      Co-Author: Erin Burnett – Queen's University, Pathology and Molecular Medicine

      Co-Author: Courtney Dwyer – Queen's University

      Co-Author: Kate Nesbitt – Queen's University

      Co-Author: Miranda Mathieson – Queen's University

      Co-Author: Laura Swystun – Queen's Universty

      Co-Author: Edward Harris – University of Nebraska-Lincoln

      Co-Author: David Lillicrap, MD – Department of Pathology and Molecular Medicine, Queen's University

    • 11:00 – 11:15 ET
      Improved maturation of human pluripotent stem cell-derived endothelial cells to study von Willebrand factor expression and function

      Presenting Author: Hongxia Fu, PhD (she/her/hers) – University of Washington

      Co-Author: Manasee Kelkar – University of Washington

      Co-Author: José López – Bloodworks Research Institute

    • 11:15 – 11:30 ET
      O-glycan and sialic acid residues differentially regulate von Willebrand factor trafficking, storage and secretion.

      Presenting Author: Ellie Karampini, PhD (she/her/hers) – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

      Co-Author: Massimiliano Garre – Super-Resolution Imaging Consortium, Royal College of Surgeons in Ireland

      Co-Author: Dearbhla Doherty, MD (she/her/hers) – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

      Co-Author: Stephanie Elliott – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

      Co-Author: Brenton Cavanagh – Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland

      Co-Author: Jamie O'Sullivan, PhD (she/her/hers) – Royal College of Surgeons in Ireland, Irish Centre for Vascular Biology, Dublin, Ireland

      Co-Author: Ingmar Schoen, PhD (he/him/his) – RCSI University of Medicine and Health Sciences

      Co-Author: James S. O'Donnell, MB, PhD – Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland,Dublin, Ireland

    • 11:30 – 11:45 ET
      Von Willebrand Factor C1-domain Mutations Promote Gain-of-function Activity

      Presenting Author: Golzar Mobayen, MSc – Centre for Haematology, Imperial College London, UK

      Co-Author: Yi Liu – University of Massachusetts

      Co-Author: Alain Chion, PhD – RCSI

      Co-Author: X. Frank Zhang – University of Massachusetts

      Co-Author: Thomas McKinnon, BSc, PhD – Imperial College London

    • 11:45 – 12:00 ET
      Whole-genome characterization of low-VWF and VWD Type 1 Patients with no Known Pathogenic VWF Variant Reveals Novel Genetic Associations

      Presenting Author: Brooke Sadler, PhD, MA – Department of Pediatrics, School of Medicine, Washington University

      Co-Author: Pamela A. Christopherson – Versiti Blood Research Institute

      Co-Author: Gabe Haller – Washington University School of Medicine

      Co-Author: Lilian Antunes – Washington University School of Medicine

      Co-Author: Carlos Cruchaga – Washington University School of Medicine

      Co-Author: Andrew Paterson – Hospital for Sick Children

      Co-Author: Paula James, MD – Department of Medicine, Queen's University, Kingston, ON, Canada

      Co-Author: David Lillicrap, MD – Department of Pathology and Molecular Medicine, Queen's University

      Co-Author: James S. O'Donnell, MB, PhD – Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland,Dublin, Ireland

      Co-Author: Robert Montgomery – Medical College of Wisconsin, Versiti Blood Research Institute, Children's Research Institute

      Co-Author: Jorge Di Paola, MD (he/him/his) – Washington University School of Medicine