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    State-of-the-Art Session

    Platelet Disorders, von Willebrand Disease and Thrombotic Microangiopathies

    Advances in VWD: Translational/Bench to Bedside

    SOA 15.3 - Endothelial Cell Biology/VWF

    Tuesday, June 27, 2023
    08:50 – 09:15 ET
    Room: 517
    Session Available As: Live-Stream and On-Demand

      Speaker(s)

    • Ruben Bierings, PhD

      Principal investigator
      Department of Hematology, Erasmus MC, University Medical Center Rotterdam, the Netherlands
      Rotterdam, Zuid-Holland, Netherlands

    Please view the 2023 RPTH State-of-the-Art Illustrated Capsules here.

    Learning Objectives:

    • Upon completion, participant will be able to describe how endothelial cells store the hemostatic protein Von Willebrand factor in specific secretory organelles called Weibel-Palade bodies.
    • Upon completion, participant will be able to describe how Weibel-Palade bodies during their maturation process recruit a collection of membrane proteins that enable their intracellular trafficking.
    • Upon completion, participant will be able to describe the processes and molecules that control exocytosis of Weibel-Palade bodies and thereby the regulated secretion of Von Willebrand factor and other Weibel-Palade body cargo by endothelial cells.