OC 73 - Cofactor Regulation of Coagulation Pathways

Moderator(s)

• 

  James Fredenburgh, PhD

  Research Associate
  McMaster University | Thrombosis and Atherosclerosis Research Institute (TaARI)
  Hamilton, Ontario, Canada
• 

  Rida Malik, HBSc

  PhD Candidate
  Medical Sciences
  McMaster University | Thrombosis and Atherosclerosis Research Institute (TaARI)
  Hamilton, Ontario, Canada

Presentations:

• 10:15 – 10:30 ET

  Targeted Genetic Disruption of Tissue Factor Pathway Inhibitor (TFPI) Alpha Results in Complete Embryonic Lethality in Mice with Factor V Leiden (FVL)
  

  Presenting Author: Amy E. Siebert, MS, PhD (she/her/hers) – Versiti Blood Research Institute

  Co-Author: Susan A. Maroney – Versiti Blood Research Institute

  Co-Author: Nicholas D. Martinez – Versiti Blood Research Institute

  Co-Author: Alan E. Mast, MD, PhD (he/him/his) – Versiti
• 10:30 – 10:45 ET

  Cryo-EM Structure of Coagulation Factor V short
  

  Co-Author: Bassem M. Mohammed, BPharm, PhD (he/him/his) – Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

  Co-Author: Leslie A. Pelc – Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

  Co-Author: Michael J. Rau – Washington University, St. Louis

  Presenting Author: Enrico Di Cera, MD – Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
• 10:45 – 11:00 ET

  Anticoagulant properties of Factor V activation intermediate (FVai) functioning as synergistic TFPI-cofactor with protein S
  

  Presenting Author: Björn Dahlbäck, MD, PhD (he/him/his) – Lund University

  Co-Author: Sinh Tran – Lund University, Dept Translational Medicine
• 11:00 – 11:15 ET

  Patients with protein C deficiency have increased NETosis, possibly mediated by reduced levels of circulating activated protein C
  

  Co-Author: Julia Oto – Hemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain

  Presenting Author: Raquel Herranz, MSc (she/her/hers) – Hemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain

  Co-Author: Emma Plana – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain; Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, Valencia, Spain

  Co-Author: Fernando Cana – Hemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain

  Co-Author: Maria Castaño – Hemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain

  Co-Author: Isabel Aleman-Cabrera – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain

  Co-Author: Amando Blanquer – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain; Thrombosis and Haemostasis Unit, Haematology Service, La Fe University and Polytechnic Hospital, Valencia, Spain

  Co-Author: Ana Cid – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain; Thrombosis and Haemostasis Unit, Haematology Service, La Fe University and Polytechnic Hospital, Valencia, Spain

  Co-Author: Saturnino Haya – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain; Thrombosis and Haemostasis Unit, Haematology Service, La Fe University and Polytechnic Hospital, Valencia, Spain

  Co-Author: Fernando Ferrando – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain; Thrombosis and Haemostasis Unit, Haematology Service, La Fe University and Polytechnic Hospital, Valencia, Spain

  Co-Author: Santiago Bonanad – Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain; Thrombosis and Haemostasis Unit, Haematology Service, La Fe University and Polytechnic Hospital, Valencia, Spain

  Co-Author: Pilar Medina – Hemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain
• 11:15 – 11:30 ET

  Delineating the Role of Physiologic Ligands on FVIIIa Inactivation
  

  Presenting Author: Johnathan J. Morris, PhD (he/him/his) – Children's Hospital of Philadelphia

  Co-Author: Nicole A. Parsons – Perelmen School of Medicine, University of Pennsylvania

  Co-Author: Anna R. Sternberg, PhD – Children's Hospital of Philadelphia

  Co-Author: Noelle C. Novak – Children's Hospital of Philadelphia

  Co-Author: Robert J. Davidson – Children's Hospital of Philadelphia

  Co-Author: Lindsey A. George, MD – University of Pennsylvania