PB1527 - Sticky Platelet Syndrome and Pregnancy Complications – 18 Years´ Experience in National Center of Hemostasis and Thrombosis in Slovak Republic

Tuesday, June 27, 2023

18:30 – 19:30 ET

Room: Exhibition

Co-Author(s)

LL

Lenka Lisá

physician - hematologist
Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Depatment of Hematology and Transfusion medicine, University Hospital in Martin, National Center of Hemostasis and Thrombosis, Slovak Republic
Martin, Zilina, Slovakia

Co-Author(s)

MD

Miroslava Dobrotová

physician-hematologist
National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusion Medicine, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia
Martin, Zilina, Slovakia
IP

Ivana Plameňová

physician - hematologist
Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Depatment of Hematology and Transfusion medicine, University Hospital in Martin, National Center of Hemostasis and Thrombosis, Slovak Republic
Martin, Zilina, Slovakia

Presenting Author(s)

Juraj Sokol, PhD.

researcher
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin
Martin, Zilina, Slovakia

Co-Author(s)

Jana Zolkova, DSc, PhD (she/her/hers)

laboratory researcher
National Centre of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Slovakia
Martin, Zilina, Slovakia
PH

Pavol Holly

physician-hematologist
National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusion Medicine, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia
Martin, Zilina, Slovakia
JI

Jela Ivanková

laboratory researcher
National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusion Medicine, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia
Martin, Zilina, Slovakia
Jan Stasko, MD, PhD (he/him/his)

university professor
National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusion Medicine, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia
Martin, Zilina, Slovakia

Background: Pregnancy is a physiological thrombophilic condition, which, however, presents an increased risk of thrombosis, especially in women with congenital thrombophilia. Sticky platelet syndrome (SPS) can manifest itself in pregnancy with arterial and venous thrombosis, but also often with various pregnancy complications, such as repeated early abortions, late abortions, premature birth or stillbirth.

Aims: The aims of the study were to determine the occurrence of pregnancy complications in patients with a confirmed diagnosis of SPS, possibilities of thromboprophylaxis, family occurrence of thrombotic events or thrombophilia and to evaluate success of next pregnancy in the group of 160 patients examined in the years 2004-2022 in National Center of Hemostasis and Thrombosis in Martin, Slovak Republic.

Methods: After taking anamnestic data and clinical examination, thrombophilic screening including light transmission aggregometry according to the method of Mammen was performed. Diagnosis of SPS was confirmed by diagnostic criteria of Mammen and Bick.

Results: The median age in the group was 33 years. Most often, we confirmed type II SPS - in 99 women (62%). We recorded 134 early abortions (up to the 12th week of pregnancy), 36 patients had at least 1 late abortion (after the 12th week of pregnancy), 11 foetus mortus and 13 premature birth. The number of early abortions ranged from 1 to 6. 153 patients (95.67%) were prescribed acetylsalicylic acid treatment, mostly at a dose of 100 mg per day. 76 (47.5%) patients after confirmation of SPS diagnosis became pregnant. In 74 (97%) patients on thromboprophylaxis with acetylsalicylic acid the pregnancy was successful, without significant bleeding complications.

Conclusion(s): Based on our clinical experience, there is a population of women with pregnancy complications who clearly benefit from the diagnosis of sticky platelet syndrome and thromboprophylaxis with acetylsalicylic acid. Supported by Grant VEGA1/0250/22 and grant KEGA 056UK-4/2022.